| Variables | Baseline | Univariate HR (95% CI) | p-value | Multivariate HR (95% CI) | p-value |
| Subjects | 114 | 107 | |||
| Age years | 56.9±13.8 | 1.05 (1.01–1.09) | 0.008 | 1.06 (1.01–1.11) | 0.02 |
| Male | 48 (42.1) | 0.94 (0.42–2.13) | 0.89 | ||
| BSA m2 | 1.9±0.2 | 0.98 (0.96–1.00) | 0.02# | ||
| Systolic BP mmHg | 128.3±19.8 | 1.00 (0.98–1.02) | 0.98 | ||
| Diastolic BP mmHg | 81.6±12.7 | 0.99 (0.96–1.02) | 0.45 | ||
| NYHA FC I/II/III/IV | 2/25/79/8 | 0.94 (0.44–2.03) | 0.88 | ||
| 6MWD m | 369±128 | 1.01 (0.97–1.04) | 0.73 | ||
| Cardiac evaluation | |||||
| Mean PAP mmHg | 41.2±10.2 | 1.01 (0.97–1.05) | 0.68 | ||
| PVR dyn·s·cm−5 | 759±422 | 1.09 (0.98–1.21) | 0.10 | ||
| Cardiac output L·min−1 | 4.1±1.2 | 0.60 (0.38–0.95) | 0.03 | 0.85 (0.52–1.39) | 0.52 |
| Heart rate beats per min | 77.1±14.9 | 0.98 (0.95–1.01) | 0.18 | ||
| LVEF % | 62.2±9.4 | 1.05 (1.01–1.09) | 0.02 | 1.05 (1.01–1.10) | 0.03 |
| VC L | 3.6±0.9 | 0.84 (0.39–1.85) | 0.67 | ||
| FEV1 L | 2.6±0.8 | 0.67 (0.25–1.82) | 0.43 | ||
| Oxygen saturation % | 94.3±2.6 | 0.93 (0.80–1.09) | 0.36 | ||
| CT-scan | |||||
| PA diameter mm | 35.7±6.0 | 1.09 (1.02–1.16) | 0.02 | ||
| Ao diameter mm | 32.0±4.7 | 1.09 (1.00–1.18) | 0.06 | ||
| PA/Ao | 1.1±0.2 | 1.06 (0.10–11.4) | 0.96 | ||
| PA/BSA mm·m−2 | 19.0±3.9 | 1.29 (1.14–1.46) | <0.001 | 1.20 (1.04–1.39) | 0.01 |
Data are presented as n, n (%) or mean±sd, unless otherwise stated. HR: hazard ratio; BSA: body surface area; BP: blood pressure; NYHA FC: New York Heart Association functional class; 6MWD: 6-min walk distance; PAP: pulmonary artery pressure; PVR: pulmonary vascular resistance; LVEF: left ventricular ejection fraction; VC: vital capacity; FEV1: forced expiratory volume in 1 s; CT: computed tomography; PA: pulmonary artery; Ao: aorta; #: per 0.1 m2.