| All cases | ERCC1 | p-value | TS | p-value | ALK-negative | ALK-positive | p-value | EGFR wild-type | EGFR mutated | p-value | KRAS wild-type | KRAS mutated | p-value | BRAF wild-type | BRAF mutated | p-value | |
| All cases | 425 (100) | 57.9±4.1 | 45.5±2.9 | 419 (98.6) | 6 (1.4) | 359 (84.5) | 66 (15.5) | 265 (62.4) | 160 (37.6) | 408 (96) | 17 (4) | ||||||
| Age | 0.090# | 0.045# | 0.691¶ | 0.283# | 0.548¶ | 0.806¶ | |||||||||||
| Below mean | 196 (46.1) | 51.7±6.0 | 37.9±4.0 | 194 (99) | 2 (1) | 170 (86.7) | 26 (13.3) | 119 (60.7) | 77 (39.3) | 189 (96.4) | 7 (3.6) | ||||||
| Above mean | 229 (53.9) | 64.5±5.8 | 52.3±4.3 | 225 (98.3) | 4 (1.7) | 189 (82.5) | 40 (17.5) | 146 (63.8) | 83 (36.2) | 219 (95.6) | 10 (4.4) | ||||||
| Sex | 0.995# | 0.989# | 0.677¶ | 0.008¶ | 0.018¶ | 0.802¶ | |||||||||||
| Male | 264 (62.1) | 60.3±5.5 | 45.6±3.8 | 261 (98.9) | 3 (1.1) | 233 (88.3) | 31 (11.7) | 153 (58) | 111 (42) | 254 (96.2) | 10 (3.8) | ||||||
| Female | 161 (37.9) | 56.3±6.3 | 45.8±4.9 | 158 (98.1) | 3 (1.9) | 126 (78.3) | 35 (21.7) | 112 (69.6) | 49 (30.4) | 154 (95.7) | 7 (4.3) | ||||||
| Smoking status | 0.023# | 0.171# | 0.388¶ | 0.001¶ | 0.003¶ | 0.629¶ | |||||||||||
| Never-smoker | 34 (9.3) | 87.5±16.1 | 55.3±10.6 | 33 (97.1) | 1 (2.9) | 22 (64.7) | 12 (35.3) | 29 (85.3) | 5 (14.7) | 32 (94.1) | 2 (5.9) | ||||||
| Smoker | 332 (90.7) | 55.7±4.8 | 43.8±3.4 | 328 (98.8) | 4 (1.2) | 290 (87.3) | 42 (12.7) | 195 (58.7) | 137 (41.3) | 320 (96.4) | 12 (3.6) | ||||||
| UICC stage | 0.106+ | <0.001+ | 0.483§ | 0.841§ | 0.715§ | 0.154§ | |||||||||||
| I | 176 (41.4) | 68.5±6.9 | 60.1±5.2 | 172 (97.7) | 4 (2.3) | 147 (83.5) | 29 (16.5) | 115 (65.3) | 61 (34.7) | 171 (97.2) | 5 (2.8) | ||||||
| II | 94 (22.1) | 37.7±6.8 | 36.7±6.0 | 94 (100) | 0 (0) | 83 (88.3) | 11 (11.7) | 53 (56.4) | 41 (43.6) | 90 (95.7) | 4 (4.3) | ||||||
| III | 143 (33.6) | 58.4±7.0 | 34.1±4.0 | 141 (98.6) | 2 (1.4) | 120 (83.9) | 23 (16.1) | 88 (61.5) | 55 (38.5) | 137 (95.8) | 6 (4.2) | ||||||
| IV | 12 (2.8) | 67.3±35.5 | 33.2±13.4 | 12 (100) | 0 (0) | 9 (75) | 3 (25) | 9 (75) | 3 (25) | 10 (83.3) | 2 (16.7) | ||||||
| Tumour stage | 0.106+ | 0.004+ | 0.183§ | 0.319§ | 0.072§ | 0.587§ | |||||||||||
| T1 | 78 (18.4) | 79.7±11.5 | 51.1±7.9 | 76 (97.4) | 2 (2.6) | 64 (82.1) | 14 (17.9) | 53 (67.9) | 25 (32.1) | 76 (97.4) | 2 (2.6) | ||||||
| T2 | 268 (63.1) | 57.9±5.3 | 50.3±3.8 | 264 (98.5) | 4 (1.5) | 224 (83.6) | 44 (16.4) | 171 (63.8) | 97 (36.2) | 255 (95.1) | 13 (4.9) | ||||||
| T3 | 67 (15.7) | 33.7±6.8 | 20.6±4.4 | 67 (100) | 0 (0) | 62 (92.5) | 5 (7.5) | 33 (49.3) | 34 (50.7) | 67 (100) | 0 (0) | ||||||
| T4 | 12 (2.8) | 67.3±21.2 | 35.9±15.5 | 12 (100) | 0 (0) | 9 (75) | 3 (25) | 8 (66.7) | 4 (33.3) | 10 (83.3) | 2 (16.7) | ||||||
| Nodal status | 0.732+ | 0.031+ | 0.807§ | 0.102§ | 0.791§ | 0.515§ | |||||||||||
| N0 | 230 (54.1) | 60.8±5.8 | 54.3±4.5 | 226 (98.3) | 4 (1.7) | 200 (87) | 30 (13) | 144 (62.6) | 86 (37.4) | 222 (96.5) | 8 (3.5) | ||||||
| N1 | 76 (17.9) | 47.5±8.0 | 38.5±6.3 | 76 (100) | 0 (0) | 63 (82.9) | 13 (17.1) | 45 (59.2) | 31 (40.8) | 73 (96.1) | 3 (3.9) | ||||||
| N2 | 116 (27.3) | 61.6±8.5 | 33.2±4.4 | 115 (99.1) | 1 (0.9) | 94 (81) | 22 (19) | 73 (62.9) | 43 (37.1) | 110 (94.8) | 6 (5.2) | ||||||
| N3 | 3 (0.7) | 45.0±45.0 | 30.0±30.0 | 2 (66.7) | 1 (33.3) | 2 (66.7) | 1 (33.3) | 3 (100) | 0 (0) | 3 (100) | 0 (0) | ||||||
| Distant metastases | 0.509# | 0.372# | 0.699¶ | 0.388¶ | 0.221¶ | 0.067¶ | |||||||||||
| M0 | 414 (97.4) | 58.3±4.2 | 46.1±3.0 | 338 (83) | 69 (17) | 351 (84.8) | 63 (15.2) | 256 (61.8) | 158 (38.2) | 399 (96.4) | 15 (3.6) | ||||||
| M1 | 11 (2.6) | 67.3±35.2 | 33.2±13.4 | 10 (90.9) | 1 (9.1) | 8 (72.7) | 3 (27.3) | 9 (81.8) | 2 (18.2) | 9 (81.8) | 2 (18.2) | ||||||
| Growth pattern | 0.017+ | 0.111+ | 0.406ƒ | 0.020ƒ | 0.630ƒ | 0.459ƒ | |||||||||||
| Lepidic | 30 (7.5) | 90.4±18.4 | 58.2±12.9 | 30 (100) | 0 (0) | 23 (76.7) | 7 (23.3) | 19 (63.3) | 11 (36.7) | 30 (100) | 0 (0) | ||||||
| Acinar | 176 (43.9) | 63.1±6.6 | 51.2±5.0 | 171 (97.2) | 5 (2.8) | 143 (81.2) | 33 (18.8) | 119 (67.6) | 57 (32.4) | 169 (96) | 7 (4) | ||||||
| Solid | 149 (37.2) | 47.0±6.5 | 39.9±4.1 | 148 (99.3) | 1 (0.7) | 135 (90.6) | 14 (9.4) | 88 (59.1) | 61 (40.9) | 141 (94.6) | 8 (5.4) | ||||||
| Papillary | 21 (5.2) | 41.9±17.1 | 29.4±16.4 | 21 (100) | 0 (0) | 18 (85.7) | 3 (14.3) | 13 (61.9) | 8 (38.1) | 21 (100) | 0 (0) | ||||||
| Micropapillary | 25 (6.2) | 73.9±19.9 | 48.0±13.9 | 25 (100) | 0 (0) | 17 (68) | 8 (32) | 16 (64) | 9 (36) | 23 (92) | 2 (8) | ||||||
| Type | 0.964# | 0.498# | 1.000¶ | 0.366¶ | 0.087¶ | 1.000¶ | |||||||||||
| Conventional | 416 (97.9) | 58.6±4.2 | 45.6±3.0 | 410 (98.6) | 6 (1.4) | 350 (84.1) | 66 (15.9) | 262 (63) | 154 (37) | 399 (95.9) | 17 (4.1) | ||||||
| Invasive mucinous | 9 (2.1) | 59.3±25.7 | 52.9±18.4 | 9 (100) | 0 (0) | 9 (100) | 0 (0) | 3 (33.3) | 6 (66.7) | 9 (100) | 0 (0) | ||||||
| CK7 | 0.310# | 0.580# | 1.000¶ | 0.707¶ | 1.000¶ | 0.554¶ | |||||||||||
| Negative | 14 (3.3) | 22.5±7.6 | 32.9±15.8 | 14 (100) | 0 (0) | 13 (92.9) | 1 (7.1) | 9 (64.3) | 5 (35.7) | 14 (100) | 0 (0) | ||||||
| Positive | 404 (96.7) | 57.8±4.2 | 45.9±3.1 | 398 (98.6) | 6 (1.5) | 339 (83.9) | 65 (16.1) | 250 (61.9) | 154 (38.1) | 387 (95.8) | 17 (4.2) | ||||||
| TTF1 | 0.007# | 0.026# | 1.000¶ | 0.685¶ | 1.000¶ | 1.000¶ | |||||||||||
| Negative | 52 (12.4) | 29.1±8.7 | 28.5±6.6 | 52 (100) | 0 (0) | 43 (82.7) | 9 (17.3) | 32 (61.5) | 20 (38.5) | 50 (96.2) | 2 (3.8) | ||||||
| Positive | 366 (87.6) | 60.6±4.4 | 47.9±3.3 | 360 (98.4) | 6 (1.6) | 310 (84.7) | 56 (15.3) | 226 (61.7) | 140 (38.3) | 351 (95.9) | 15 (4.1) | ||||||
| Napsin | 0.080# | 0.104# | 0.343¶ | 0.061¶ | 1.000¶ | 0.263¶ | |||||||||||
| Negative | 103 (24.5) | 43.4±7.0 | 38.8±5.9 | 103 (100) | 0 (0) | 93 (90.3) | 10 (9.7) | 64 (62.1) | 39 (37.9) | 101 (98.1) | 2 (1.9) | ||||||
| Positive | 317 (75.5) | 61.9±4.9 | 47.8±3.5 | 311 (98.1) | 6 (1.9) | 261 (82.3) | 56 (17.7) | 197 (62.1) | 120 (37.9) | 302 (95.3) | 15 (4.7) |
Data are presented as n (%) or mean±se, unless otherwise stated. Data were missing in a few cases in smoking status (n=59), growth pattern (n=15), cytokeratin (CK)7 (n=7), thyroid transcription factor (TTF)1 (n=7), napsin (n=5), excision repair cross-complementing rodent repair deficiency complementation group 1 protein (ERCC1) (n=41) and thymidylate synthase (TS) (n=30). ALK: anaplastic lymphoma kinase; EGFR: epidermal growth factor receptor; KRAS: V-Ki-ras2 Kirsten rat sarcoma viral oncogene homologue; BRAF: v-Raf murine sarcoma viral oncogene homologue B1; UICC: Union for International Cancer Control. #: Mann–Whitney U-test; ¶: Fisher’s exact test; +: Kruskal–Wallis test; §: Chi-squared test for trends; ƒ: Chi-squared test.