Current IDSA/ATS criteria | Simplified IDSA/ATS criteria | Modified IDSA/ATS criteria |
Respiratory rate ≥30 breaths per min | Respiratory rate ≥30 breaths per min | Respiratory rate ≥30 breaths per min |
PaO2/FIO2 ratio ≤250 | PaO2/FIO2 ratio ≤250 | PaO2/FIO2 ratio ≤250 |
Multilobar infiltrates | Multilobar infiltrates | Multilobar infiltrates |
Confusion/disorientation | Confusion/disorientation | Confusion/disorientation |
Uraemia BUN level ≥20 mg·dL−1 | Uraemia BUN level ≥20 mg·dL−1 | Uraemia BUN level ≥20 mg·dL−1 |
Leukopenia WBC count <4000 cells·mm−3 | Systolic blood pressure <90 mmHg | Systolic blood pressure <90 mmHg |
Thrombocytopenia platelet count <100 000 cells·mm−3 | Acidosis | |
Hypothermia (core temperature <36°C) | ||
Hypotension requiring aggressive fluid resuscitation | ||
Additional criteria to consider | Additional criteria to consider | Additional criteria to consider |
Hypoglycaemia | Leukopenia | Leukopenia |
Acute alcoholism or alcohol withdrawal | Hypothermia | Hypothermia |
Hyponatraemia | Thrombocytopenia | Thrombocytopenia |
Unexplained metabolic acidosis | Hypoglycaemia | Hypoglycaemia |
Elevated lactate level | Hyponatraemia | Hyponatraemia |
Liver cirrhosis | Unexplained metabolic acidosis | Elevated lactate level |
Asplenia | Elevated lactate level | Liver cirrhosis |
Liver cirrhosis |
PaO2: arterial oxygen tension; FIO2: inspiratory oxygen fraction; BUN: blood urea nitrogen; WBC: white blood cell.