| IDSA/ATS minor criteria | Subjects# n | Pooled positive n (%) | Pooled OR (95% CI) | p-value | I2 % |
| Mortality | |||||
| Respiratory rate ≥30 breaths per min | 5686 | 1197 (21.1) | 3.03 (1.92–4.78) | <0.0001 | 65 |
| PaO2/FIO2 ratio ≤250 | 5686 | 1482 (26.1) | 5.62 (2.27–13.9) | 0.0002 | 93 |
| Multilobar shadowing | 5686 | 1823 (32.1) | 2.77 (1.27–6.02) | 0.01 | 90 |
| Confusion | 5686 | 897 (15.8) | 5.47 (2.81–10.7) | <0.0001 | 86 |
| Urea ≥20 mg·dL−1 | 5686 | 1502 (26.4) | 4.76 (2.92–7.77) | <0.0001 | 71 |
| White blood cell count <4000 cells·mm−3 | 5686 | 202 (3.6) | 3.04 (1.98–4.65) | <0.0001 | 0 |
| Platelet count <100 000 cells·mm−3 | 5686 | 175 (3.1) | 2.47 (1.46–4.18) | 0.0007 | 19 |
| Hypothermia¶ | 5686 | 223 (3.9) | 3.06 (1.41–6.66) | 0.005 | 61 |
| Hypotension | 5686 | 788 (13.9) | 2.39 (1.35–4.22) | 0.003 | 69 |
| ICU admission | |||||
| Respiratory rate ≥30 breaths per min | 6240 | 1385 (22.2) | 4.68 (2.94–7.44) | <0.0001 | 81 |
| PaO2/FIO2 ratio ≤250 | 6240 | 1459 (23.4) | 5.06 (3.07–8.36) | <0.0001 | 83 |
| Multilobar shadowing | 6240 | 1902 (30.5) | 3.25 (2.77–3.81) | <0.0001 | 0 |
| Confusion | 6240 | 760 (12.2) | 4.78 (2.43–9.39) | <0.0001 | 89 |
| Urea ≥20 mg·dL−1 | 6240 | 1495 (24.0) | 3.38 (2.46–4.64) | <0.0001 | 54 |
| White blood cell count <4000 cells·mm−3 | 6240 | 183 (2.9) | 4.21 (2.99–5.93) | <0.0001 | 0 |
| Platelet count <100 000 cells·mm−3 | 6240 | 187 (3.0) | 3.12 (2.19–4.46) | <0.0001 | 0 |
| Hypothermia¶ | 6240 | 295 (4.7) | 5.14 (4.09–6.46) | 0.004 | 67 |
| Hypotension | 6240 | 404 (6.5) | 3.41 (2.58–4.50) | <0.0001 | 0 |
PaO2: arterial oxygen tension; FIO2: inspiratory oxygen fraction. #: Different for each analysis because some studies only examined one end-point; ¶: <36°C.