Variables | All# | Never-smokers | Ever-smokers | ||
Without high BMI¶ | With high BMI+ | Without high BMI§ | With high BMIƒ | ||
Female sex | 2230 (53.2) | 910 (60.5) | 287 (62.3) | 841 (49.1) | 192 (37.1) |
Age years | 51.9±11.5 | 50.2±12.1 | 55.2±11.8 | 51.2±11.0 | 56.1±9.5 |
Education | |||||
Low | 274 (6.5) | 70 (4.7) | 63 (13.7) | 86 (5.0) | 55 (10.6) |
Medium | 2771 (66.1) | 971 (64.6) | 322 (69.8) | 1143 (66.7) | 335 (64.7) |
High | 1150 (27.4) | 462 (30.7) | 76 (16.5) | 484 (28.3) | 128 (24.7) |
Body measures | |||||
Height m | 1.7±0.1 | 1.7±0.1 | 1.7±0.1 | 1.7±0.1 | 1.7±0.1 |
Weight kg | 73.5±14.4 | 67.7±10.6 | 88.0±12.8 | 69.2±11.0 | 91.4±12.2 |
BMI kg·m−2 | 25.7±4.3 | 23.8±2.6 | 31.9±3.5 | 24.0±2.6 | 31.7±3.1 |
Smoking history | |||||
Current smoker | 929 (22.1) | 0 (0.0) | 0 (0.0) | 754 (44.0) | 175 (33.8) |
Pack-years## | 17 (6.0–35.0) | 15.6 (5.5–32.2) | 22.4 (9.5–42.0) | ||
Comorbidities | |||||
Cardiopulmonary¶¶ | 605 (14.4) | 173 (11.5) | 83 (18.0) | 243 (14.2) | 106 (20.5) |
Lung function | |||||
FEV1 L | 3.2±0.8 | 3.2±0.8 | 2.9±0.9 | 3.2±0.8 | 3.0±0.8 |
FVC L | 4.2±1.0 | 4.2±1.0 | 3.9±1.1 | 4.4±1.0 | 4.2±0.9 |
FEV1/FVC % | 74.7±7.5 | 76.2±6.9 | 74.7±7.0 | 74.0±7.6 | 72.8±8.1 |
FEF25–75% L·s−1 | 2.6±1.1 | 2.8±1.1 | 2.5±1.1 | 2.6±1.1 | 2.4±1.2 |
Biomarkers | |||||
Bilirubin μmol·L−1 | 7 (5–10) | 7 (6–10) | 7 (5–9) | 7 (5–10) | 7 (5–9) |
C-reactive protein μmol·L−1 | 1 (0.5–2.3) | 0.8 (0.4–1.6) | 1.9 (1.0–4.4) | 0.9 (0.5–2.0) | 2 (1.0–3.9) |
Genotypes | |||||
rs6742078 | |||||
GG | 402 (40.9) | 126 (36.7) | 46 (41.1) | 173 (43.0) | 57 (45.6) |
GT | 453 (46.1) | 171 (49.9) | 50 (44.6) | 180 (44.8) | 52 (41.6) |
TT | 127 (12.9) | 46 (13.4) | 16 (14.3) | 49 (12.2) | 16 (12.8) |
Data are presented as n, n (%), mean±sd or median (interquartile range). BMI: body mass index; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; FEF25–75%: forced expiratory flow at 25–75% of FVC. #: n=4195, with the exception of C-reative protein (n=4184) and genotypes (n=982); ¶: n=1503, with the exception of C-reactive protein (n=1498) and genotypes (n=343); +: n=461, with the exception of genotypes (n=112); §: n=1713, with the exception of C-reactive protein (n=1707) and genotypes (n=402); ƒ: n=518, with the exception of genotypes (n=125); ##: in ever-smokers only; ¶¶: self-declared heart-disease, lung emphysema, chronic bronchitis or healthcare use for breathing problems in the last 12 months.