First author [ref.] | Aliquot fraction analysed | Subjects | Age | Participants | Results | Statistics |
Khan [31] | P | 16 | 0.08–0.97 years | Neutrophil count PMN cell count above controls (n=11) PMN cell count overlapping controls (n=5) | Lower SpO2 in group with elevated PMN cell count (mean±SEM 92.8±0.9 versus 96.6±0.7, p=0.0097) Weight-for-age ns Respiratory rate ns Wisconsin chest computed tomography score ns | Independent t-test |
Sagel [57] | P | 111 | 6 months–6 years | Neutrophil elastase | Lower Shwachman scores in group with detectable free neutrophil elastase activity (63.5±8.8 versus 69.7±5.5, p<0.0001) | Not reported |
Hull [58] | F | 32 | Presence of inflammation (PMN cell count and IL-8) Inflammation (n=13) No inflammation (n=19) | Higher lipid hydroperoxide concentration in group with detectable inflammation (geometric mean 97.7 versus 21.9 μM, p<0.05) Higher γ-GT in group with detectable inflammation (geometric mean 104.2 versus 20.2 U·L−1, p<0.05) | Independent t-test |
Data are presented as n, range or mean±sd, unless otherwise stated. Patients grouped by level of inflammation (from BAL biomarkers) differ in clinical presentation (including oxidative stress). P: pooled; F: first; PMN: polymorphonuclear; SpO2: arterial oxygen saturation measured by pulse oximetry; ns: nonsignificant; IL: interleukin; γ-GT: gamma glutamyl transpeptidase.