| Change in 6MWD m·year−1 | p-value | Clinically significant loss¶ | |||
| No+ | Yes§ | p-value | |||
| Anyƒ admission during follow-up | |||||
| No | −13.8±35.9 | 0.003 | 142 (75) | 47 (25) | 0.002 |
| Yes | −32.5±51.7 | 87 (57) | 66 (43) | ||
| Number of admissionsƒ per year during follow-up | |||||
| 0 | −13.8±32.9 | 0.002¶¶ | 142 (75) | 47 (25) | 0.001¶¶ |
| >0 and ≤1 | −26.1±51.9 | 46 (63) | 27 (37) | ||
| >1 | −38.4±70.9 | 41 (52) | 39 (48) | ||
| Cause of admission## | |||||
| Only COPD | −36.2±56.2 | 0.236++ | 36 (47) | 41 (53) | 0.040++ |
| Nonrespiratory | −24.2±48.9 | 31 (71) | 12 (29) | ||
| Mixed causes | −28.2±48.7 | 20 (61) | 13 (39) | ||
| Quartiles of cumulative hospital stay## days | |||||
| 1 to ≤5 | −29.8±37.6 | 0.610¶¶ | 25 (61) | 16 (39) | 0.682¶¶ |
| >5 to ≤13 | −33.1±48.7 | 20 (51) | 18 (49) | ||
| >13 to ≤28 | −29.1±49.8 | 23 (64) | 13 (36) | ||
| >28 | −38.1±51.5 | 19 (50) | 19 (50) | ||
| Quartiles of time from last discharge to second evaluation## days | |||||
| 0 to ≤103 | −36.3±42.1 | 0.445¶¶ | 21 (52) | 18 (48) | 0.735¶¶ |
| >103 to ≤206 | −33.8±48.9 | 23 (60) | 15 (40) | ||
| >206 to ≤363 | −36.1±49.4 | 20 (53) | 18 (47) | ||
| >363 | −25.8±46.4 | 23 (60) | 15 (40) | ||
Data are presented as mean±sd or n (%), unless otherwise stated. #: presented both as a continuous variable and according to clinically significant change, for a better understanding of the effect of hospitalisations; each combination of hospitalisation variables and change in the 6MWD is a single unadjusted model. ¶: ≥35 m·year−1. +: n=229. §: n=113. ƒ: all causes. ##: n=153. ¶¶: p-value for trend. ++: “only COPD” versus “nonrespiratory”; “mixed causes” is only presented for descriptive purposes.