Chemokine | Basal cells | Ciliated cells | ||||
Control | RSV-infected | Fold change¶ | Control | RSV-infected | Fold change¶ | |
Eotaxin CCL11 pg·mL−1 | 113 (111–160) | 159 (125–299) | 1.0 (1.0–1.6) | 409 (307–477) | 435 (408–457) | 1.1 (1.0–1.3) |
MIP-1β CCL4 pg·mL−1 | 3 (1–7) | 13 (4–41) | 3.9 (1.2–5.5) | 33 (17–54) | 37 (33–52) | 1.3 (1.0–1.8) |
Eotaxin-3 CCL26 pg·mL−1 | 233 (190–398) | 1146 (192–7398)* | 2.1 (1.2–17.7) | 6593 (3932–11580) | 5516 (4564–8620) | 0.8 (0.7–1.1) |
TARC CCL17 pg·mL−1 | 54 (46–83) | 100 (69–189) | 1.2 (1.1–2.5) | 295 (227–415) | 339 (302–368) | 1.1 (1.0–1.3) |
MCP-1 CCL2 pg·mL−1 | 240 (186–353) | 1252 (186–5911)* | 2.8 (1.3–18.9) | 8299 (4949–15839) | 7135 (5515–14185) | 1.0 (0.6–1.4) |
MDC CCL22 pg·mL−1 | 113 (82–281) | 1753 (93–5726) | 1.9 (1.2–40.1) | 20545 (9986–23181) | 22812 (20342–30853) | 1.7 (1.1–2.6) |
MCP-4 CCL13 pg·mL−1 | 11 (6–16) | 111 (28–163)* | 7.5 (6.0–15.4) | 94 (42–134) | 274 (95–337)* | 2.5 (2.1–3.0) |
IL-8 CXCL8 pg·mL−1 | 95 (79–143) | 208 (77–554)* | 1.7 (1.1–3.4) | 594 (506–989) | 887 (692–1190)* | 1.5 (1.2–1.6) |
IP-10 CXCL10 pg·mL−1 | 95 (87–115) | 239 (103–560) | 1.8 (1.1–5.9) | 698 (433–974) | 4140 (823–19884)* | 3.5 (1.8–20.2) |
Data are presented as median (interquartile range). CCL: (C-C motif) ligand; MIP: macrophage inflammatory protein; TARC: thymus and activation regulated chemokine; MCP: monocyte chemotactic protein; MDC: macrophage-derived chemokine; IL: interleukin; CXCL: C-X-C motif chemokine; IP: interferon-γ-induced protein. #: n=8; ¶: fold change from uninfected control at same time-point. *: p<0.05 (Wilcoxon signed rank test).