| Monotherapy arm# | Doublet chemotherapy arm¶ | |||
| Grade 3 | Grade 4 | Grade 3 | Grade 4 | |
| Subjects | 26 | 2 | 32 | 1 |
| Skin disorders | 15 (58) | 16 (50) | 1 | |
| Alanine aminotransferase increase | 0 | 1 (3) | ||
| Anorexia | 8 (31) | 2 (6) | ||
| Asthenia | 7 (27) | 5 (16) | ||
| Conjunctivitis | 1 (4) | 1 (3) | ||
| Depression | 0 | 1 (3) | ||
| Diarrhoea | 3 (12) | 5 (16) | ||
| Limb oedema | 0 | 1 (3) | ||
| γ-glutamyltransferase increase | 0 | 1 (3) | ||
| Gastric haemorrhage | 1 | |||
| Gastrointestinal disorder | 1 (4) | 0 | ||
| Hemiplegia | 1 (4) | 0 | ||
| Haemoglobin decrease | 0 | 1 (3) | ||
| Interstitial pneumonitis | 1 | |||
| Mouth irritation | 2 (8) | 1 (3) | ||
| Nail infection | 0 | 1 (3) | ||
| Nausea | 1 (4) | 1 (3) | ||
| Rectal haemorrhage | 0 | 1 (3) | ||
| Reduced general condition | 0 | 2 (6) | ||
| Sensory neuropathy | 0 | 1 (3) | ||
| Subcutaneous emphysema | 0 | 1 (3) | ||
| Vomiting | 0 | 1 (3) | ||
Data are presented as n or n (%). #: n=28; ¶: n=32.