First author [ref.] | Chromosome | Gene | SNP previously reported | SNP used# | LD r2 | Position | Reference versus alternative allele | Alternative allele frequency | Phenotype A | Phenotype B | Phenotype C | Phenotype D | p-value for heterogeneity¶ | ||||
OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value | ||||||||||
Torgerson [2] | 1 | CRCT1 | rs4845783 | rs1053590 | 0.73 | 150755052 | T/C | 0.63 | 1.01 (0.85–1.20) | 0.98 | 1.03 (0.91–1.17) | 0.60 | 0.86 (0.74–0.99) | 0.06 | 1.13 (0.94–1.35) | 0.22 | 0.34 |
Ferreira [24] | 1 | IL6R | rs4129267 | 152692888 | T/C | 0.58 | 0.97 (0.83–1.13) | 0.64 | 0.88 (0.78–0.99) | 0.06 | 0.90 (0.78–1.04) | 0.25 | 0.99 (0.83–1.18) | 0.76 | 0.29 | ||
Sleiman [16] | 1 | DENND1B | rs2786098 | 195592531 | T/G | 0.77 | 0.89 (0.73–1.07) | 0.29 | 0.95 (0.82–1.09) | 0.61 | 1.00 (0.85–1.18) | 0.99 | 1.10 (0.89–1.36) | 0.43 | 0.61 | ||
Ober [29] | 1 | CHI3L1 | rs880633 | rs762625 | 0.17 | 201419424 | T/C | 0.82 | 0.85 (0.69 – 1.04) | 0.15 | 1.03 (0.88–1.21) | 0.83 | 1.04 (0.85–1.28) | 0.76 | 0.98 (0.78–1.22) | 0.92 | 0.29 |
Torgerson [2] | 1 | SRP9 | rs4653433 | 224041154 | A/G | 0.56 | 0.87 (0.74–1.02) | 0.09 | 0.95 (0.84–1.08) | 0.57 | 1.01 (0.87–1.16) | 0.79 | 0.75 (0.64–0.89) | 8.7×10−4 | 0.003 | ||
Torgerson [2] | 2 | IL1RL1 | rs10173081 | rs13431828 | 1 | 102321085 | T/C | 0.86 | 1.25 (0.98–1.61) | 0.04 | 1.37 (1.14–1.65) | 1.6×10−4 | 1.46 (1.16–1.84) | 4.4×10−4 | 1.16 (0.90–1.5) | 0.23 | 4.6×10−4 |
Gudbjartsson [18] | 2 | IL1RL1 | rs1420101 | rs17026974 | 0.85 | 102318792 | A/G | 0.73 | 0.95 (0.80–1.13) | 0.47 | 0.93 (0.81–1.07) | 0.26 | 0.86 (0.74–1.00) | 0.07 | 1.02 (0.85–1.24) | 0.82 | 0.71 |
Moffatt [1] | 2 | IL18R1 | rs3771166+ p=6.2×10−6 | 102352654 | A/G | 0.63 | 1.16 (0.98–1.36) | 0.05 | 1.14 (1.01–1.29) | 0.04 | 1.31 (1.13–1.52) | 5.2×10−4 | 1.04 (0.87–1.24) | 0.61 | 0.001 | ||
Mathias [20] | 2 | DPP10 | rs1435879 | 115209357 | G/A | 0.88 | 0.98 (0.77–1.26) | 0.95 | 0.84 (0.70–1.00) | 0.05 | 0.76 (0.62–0.93) | 0.01 | 0.99 (0.75–1.30) | 0.97 | 0.01 | ||
Torgerson [2] | 3 | RTP2 | rs2017908 | rs7616923 | 1 | 188903913 | T/G | 0.87 | 1.05 (0.83–1.33) | 0.58 | 0.99 (0.82–1.18) | 0.89 | 0.99 (0.80–1.23) | 0.87 | 0.95 (0.73–1.24) | 0.74 | 0.32 |
Torgerson [2] | 4 | EPHA5 | rs11735820 | rs7697951 | 1 | 66169736 | C/T | 0.70 | 1 (0.85–1.19) | 0.86 | 0.92 (0.81–1.04) | 0.13 | 1.09 (0.94–1.27) | 0.19 | 0.91 (0.76–1.08) | 0.29 | 0.26 |
Himes [19] | 5 | PDE4D | rs1588265 | 59405551 | G/A | 0.70 | 1.02 (0.86–1.22) | 0.94 | 0.95 (0.83–1.08) | 0.40 | 0.88 (0.76–1.03) | 0.14 | 1.00 (0.83–1.21) | 0.99 | 0.20 | ||
Torgerson [2] | 5 | TSLP | rs1837253 | 110429771 | T/C | 0.76 | 0.86 (0.72–1.03) | 0.12 | 1.15 (1.00–1.33) | 0.07 | 1.29 (1.10–1.52) | 0.002 | 1.25 (1.02–1.53) | 0.02 | 2.0×10−4 | ||
Gudbjartsson [18] | 5 | WDR36 | rs2416257 | 110463389 | T/C | 0.87 | 0.83 (0.66–1.04) | 0.13 | 1.12 (0.92–1.35) | 0.24 | 1.22 (0.98–1.51) | 0.08 | 1.12 (0.87–1.45) | 0.34 | 0.006 | ||
Moffatt [1] | 5 | SLC22A5 | rs2073643+ p=2.4×10−6 | 131751187 | T/C | 0.57 | 0.92 (0.79–1.08) | 0.32 | 0.91 (0.80–1.03) | 0.08 | 0.90 (0.78–1.04) | 0.11 | 1.03 (0.87–1.23) | 0.65 | 0.15 | ||
Li [17] | 5 | RAD50-IL13 | rs2897443 | 131957493 | T/G | 0.80 | 1.04 (0.85–1.26) | 0.78 | 0.96 (0.83–1.12) | 0.57 | 0.77 (0.66–0.91) | 0.006 | 0.96 (0.78–1.17) | 0.67 | 0.22 | ||
Moffatt [1] | 5 | IL13 | rs1295686+ p=1.8×10−6 | 132023742 | T/C | 0.80 | 1.10 (0.89–1.36) | 0.50 | 0.99 (0.85–1.16) | 0.99 | 0.87 (0.74–1.03) | 0.18 | 1.00 (0.81–1.24) | 0.89 | 0.10 | ||
Torgerson [2] | 5 | GALNT10 | rs10064618 | 153752482 | A/G | 0.61 | 1.00 (0.85–1.18) | 0.91 | 1.04 (0.92–1.17) | 0.66 | 0.97 (0.84–1.11) | 0.52 | 1.05 (0.88–1.25) | 0.51 | 0.26 | ||
Mathias [20] | 5 | ADRA1B | rs10515807 | 159297576 | A/G | 0.80 | 1.17 (0.95–1.43) | 0.15 | 1.01 (0.87–1.17) | 0.83 | 1.10 (0.92–1.31) | 0.23 | 1.17 (0.95–1.45) | 0.16 | 0.28 | ||
Moffatt [1] | 6 | HLA-DQ | rs9273349+ p=4.4×10−8 | 32733847 | T/C | 0.59 | 1.15 (0.97–1.36) | 0.12 | 1.28 (1.13–1.45) | 7.3×10−5 | 1.33 (1.14–1.54) | 1.7×10−4 | 1.19 (0.99–1.43) | 0.06 | 1.3×10−5 | ||
Noguchi [22] | 6 | HLADP | rs987870 | 33150858 | G/A | 0.83 | 1.16 (0.93–1.46) | 0.13 | 0.87 (0.74–1.02) | 0.18 | 0.79 (0.66–0.94) | 0.03 | 0.9 (0.72–1.13) | 0.33 | 0.01 | ||
Torgerson [2] | 8 | FBXO43 | rs2453626 | 101207073 | T/C | 0.55 | 1.02 (0.87–1.2) | 0.59 | 0.95 (0.84–1.07) | 0.41 | 1.10 (0.95–1.28) | 0.23 | 1.14 (0.96–1.35) | 0.13 | 0.27 | ||
Moffatt [1] | 9 | IL33 | rs1342326+ p=1.2×10−7 | 6180076 | C/A | 0.81 | 0.83 (0.69–1.01) | 0.07 | 0.78 (0.68–0.90) | 0.003 | 0.76 (0.64–0.90) | 0.006 | 0.91 (0.73–1.13) | 0.36 | 0.005 | ||
Torgerson [2] | 9 | IL33 | rs2381416 | rs928413 | 1 | 6203387 | G/A | 0.71 | 0.81 (0.68–0.97) | 0.02 | 0.78 (0.68–0.89) | 7.2×10−4 | 0.73 (0.63–0.84) | 1.6×10−4 | 0.89 (0.74–1.08) | 0.22 | 8.1×10−5 |
Gudbjartsson [18] | 9 | IL33 | rs3939286 | 6200099 | T/C | 0.72 | 0.81 (0.68–0.96) | 0.02 | 0.79 (0.69–0.91) | 0.002 | 0.74 (0.64–0.86) | 3.1×10−4 | 0.90 (0.74–1.08) | 0.23 | 2.6×10−4 | ||
Hancock [21] | 9 | TLE4 | rs2378383 | 81229182 | G/A | 0.89 | 1.00 (0.77–1.30) | 0.94 | 0.89 (0.74–1.08) | 0.16 | 1.11 (0.88–1.39) | 0.52 | 0.88 (0.68–1.14) | 0.44 | 0.66 | ||
Ferreira [24] | 11 | LRRC32_GARP | rs7130588 | 75948331 | G/A | 0.64 | 0.99 (0.84–1.16) | 0.89 | 0.88 (0.78–1.00) | 0.08 | 0.89 (0.76–1.03) | 0.16 | 1.00 (0.84–1.20) | 0.94 | 0.08 | ||
Torgerson [2] | 11 | C11orf71 | rs11214966 | rs12223585 | 0.83 | 113740900 | T/C | 0.94 | 1.31 (0.93–1.85) | 0.11 | 1.28 (0.99–1.66) | 0.05 | 1.04 (0.78–1.38) | 0.80 | 1.01 (0.72–1.41) | 0.87 | 0.62 |
Torgerson [2] | 12 | RASSF8 | rs16929496 | rs10842635 | 0.96 | 25924553 | A/G | 0.78 | 1.04 (0.85–1.26) | 0.52 | 1.11 (0.95–1.29) | 0.16 | 1.16 (0.97–1.39) | 0.17 | 1.19 (0.96–1.49) | 0.08 | 0.41 |
Moffatt [1] | 15 | RORA | rs11071559+ p=5.9×10−6 | 58857280 | T/C | 0.87 | 0.98 (0.77–1.25) | 0.87 | 1.22 (1.00–1.49) | 0.03 | 1.48 (1.17–1.86) | 3.4×10−4 | 1.26 (0.95–1.65) | 0.08 | 0.02 | ||
Moffatt [1] | 15 | SMAD3 | rs744910+ p=3.4×10−7 | 65233839 | G/A | 0.50 | 0.98 (0.84–1.15) | 0.71 | 0.83 (0.74–0.94) | 0.002 | 0.85 (0.74–0.97) | 0.03 | 0.82 (0.69–0.97) | 0.02 | 0.002 | ||
Torgerson [2] | 17 | AURKB | rs9891949 | rs7503353 | 0.43 | 8048704 | G/T | 0.50 | 1.01 (0.87–1.18) | 0.90 | 1.00 (0.89–1.12) | 0.90 | 0.98 (0.85–1.12) | 0.78 | 1.01 (0.85–1.19) | 0.99 | 0.92 |
Moffatt [1] | 17 | GSDMB | rs2305480+ p=1.2×10−7 | 35315722 | A/G | 0.56 | 1.00 (0.86–1.18) | 0.86 | 1.12 (0.99–1.26) | 0.11 | 1.26 (1.09–1.46) | 0.004 | 1.14 (0.95–1.36) | 0.12 | 0.03 | ||
Moffatt [15] | 17 | ORMDL3/GSDMB | rs7216389 | 35323475 | C/T | 0.52 | 1.00 (0.85–1.18) | 0.97 | 1.09 (0.97–1.23) | 0.25 | 1.25 (1.08–1.44) | 0.006 | 1.13 (0.95–1.35) | 0.12 | 0.05 | ||
Moffatt [1] | 17 | GSDMA | rs3894194+ p=2.0×10−8 | 35375519 | A/G | 0.53 | 0.95 (0.80–1.12) | 0.49 | 0.94 (0.83–1.06) | 0.46 | 0.85 (0.74–0.98) | 0.06 | 0.86 (0.72–1.03) | 0.06 | 0.32 | ||
Mathias [20] | 17 | GBNA13 | rs3972219 | 60448995 | G/A | 0.95 | 1.27 (0.87–1.85) | 0.30 | 1.07 (0.82–1.40) | 0.72 | 1.06 (0.78–1.44) | 0.69 | 1.00 (0.70–1.42) | 0.99 | 0.72 | ||
Torgerson [2] | 19 | C19orf2 | rs335016 | rs34707 | 1 | 35068558 | T/G | 0.75 | 0.87 (0.73–1.05) | 0.18 | 0.93 (0.81–1.07) | 0.37 | 0.96 (0.82–1.13) | 0.68 | 1.24 (1.01–1.53) | 0.03 | 0.40 |
Mathias [20] | 20 | PRNP | rs6052761 | 4605017 | C/T | 0.89 | 1.05 (0.81–1.36) | 0.61 | 0.79 (0.65–0.95) | 0.02 | 0.85 (0.69–1.05) | 0.12 | 1.25 (0.92–1.68) | 0.12 | 0.04 | ||
Moffatt [1] | 22 | IL12RB | rs2284033+ p=5.5×10−7 | 35863980 | A/G | 0.57 | 1.00 (0.85–1.17) | 0.94 | 1.04 (0.92–1.17) | 0.51 | 1.21 (1.05–1.40) | 0.01 | 1.16 (0.98–1.37) | 0.08 | 0.06 |
Bold represents associations with p≤0.001. LD: linkage disequilibrium. #: if the SNP reported in the literature was not available in our genotyped data, we reported association with the available SNP showing the strongest LD with the initial reported SNP; ¶: p-value for the heterogeneity of the association observed between the asthma phenotypes, assessed using the multinomial model, as described in Morris et al. [27]; +: because the GABRIEL study (Moffatt et al. [1]) includes participants from European Community Respiratory Health Survey (ECHRS), the Study on Air Pollution and Lung Disease in Adults (SAPALDIA) and the Epidemiological Study on the Genetics and Environment of Asthma (EGEA), the association from the GABRIEL study after excluding these three studies in the meta-analysis is presented.