Table 5– Survival analysis of pulmonary function tests and CALIPER measurement

Difference	Univariable			Adjusted
Difference	HR	95% CI	p-value	HR	95% CI	p-value
TLC % pred^#	1.19	0.67–2.12	0.55	4.17	1.42–12.0	0.009
FVC % pred^#	1.10	0.76–1.62	0.60	1.54	0.95–2.51	0.081
FEV₁ % pred^#	1.21	0.82–1.79	0.33	1.46	0.93–2.29	0.099
D_LCO % pred^#	1.42	0.93–2.16	0.11	2.14	1.27–3.60	0.004
Total emphysema^¶	1.19	0.87–1.65	0.28	1.29	0.92–1.79	0.14
Total emphysema^¶ %	1.10	0.85–1.41	0.48	1.16	0.87–1.54	0.32
Total GG^¶	1.40	1.05–1.85	0.022	1.30	0.88–1.90	0.19
Total GG^¶ %	1.29	0.98–1.70	0.072	1.21	0.85–1.73	0.28
Total reticular^¶	1.35	0.91–1.99	0.14	1.91	1.21–3.0	0.006
Total reticular^¶ %	1.38	1.03–1.84	0.032	1.93	1.30–2.89	0.001
Total honeycombing^¶	0.95	0.74–1.21	0.68	1.03	0.80–1.31	0.84
Total honeycombing^¶ %	0.94	0.74–1.20	0.62	1.02	0.80–1.29	0.90
Total ILD^¶	1.47	1.08–2.0	0.016	1.70	1.19–2.43	0.003
Total ILD^¶ %	1.30	0.99–1.71	0.062	1.52	1.08–2.15	0.017
Emphysema radiologist 1^¶	1.32	0.89–1.97	0.17	1.32	0.88–1.98	0.18
Emphysema radiologist 2^¶	0.82	0.52–1.29	0.38	1.48	0.79–2.77	0.22
GG radiologist 1^¶	1.16	0.86–1.57	0.32	1.40	0.97–2.02	0.070
GG radiologist 2^¶	1.02	0.77–1.35	0.88	1.24	0.92–1.67	0.16
Honeycombing radiologist 1^¶	1.07	0.74–1.54	0.73	1.12	0.72–1.75	0.61
Honeycombing radiologist 2^¶	1.10	0.79–1.54	0.56	1.11	0.75–1.65	0.60
Reticular radiologist 1^¶	1.11	0.84–1.47	0.46	1.20	0.87–1.64	0.27
Reticular radiologist 2^¶	1.14	0.70–1.84	0.60	1.03	0.63–1.68	0.92
Change radiologist 1
Improved/stable	Ref.			Ref.
Worse	2.1	1.09–4.04	0.026	2.22	1.08–4.56	0.029
Change radiologist 2
Improved/stable	Ref.			Ref.
Worse	1.86	0.96–3.61	0.066	2.50	1.12–5.54	0.025

CALIPER: Computer-Aided Lung Informatics for Pathology, Evaluation and Ratings; HR: hazard ratio; TLC: total lung capacity; % pred; % predicted; FVC: forced vital capacity; FEV₁: forced expiratory volume in 1 second; D_LCO: diffusing capacity of the lung for carbon monoxide; ILD: interstitial lung disease (ground glass (GG) + reticular + honeycombing); Ref: reference.^#: HRs are for a 15-unit change in D_LCO % pred and a 10-unit change in FEV₁ % pred, FVC % pred and TLC % pred; ^¶: HRs are for a sd change.