Table 4– Diagnostic accuracy of induced sputum smear microscopy stratified by patient setting, HIV status and CD4 cell count
All#OutpatientsInpatientsHIV infectedHIV uninfectedCD4 >200 cells·μL−1§CD4 ≤200 cells·μL−1§
Subjects48519029521013610489
Sensitivity49 (39–59) 47/9632ƒ (14–50) 8/2555ƒ (43–67) 39/7153 (40–66) 27/5150 (28–72) 8/1658 (39–76) 14/2450 (31–69) 12/24
Specificity98 (97–100) 383/38999 (97–100) 164/16598 (95–99) 219/22498 (94–99) 155/159100 (97–100) 120/12099 (93–100) 79/8095 (87–98) 62/65
PPV89 (77–95) 47/5389 (57–98) 8/989 (76–95) 39/4487 (71–95) 27/31100 (68–100) 8/893 (70–99) 14/1580 (55–93) 12/15
NPV89 (85–91) 383/43291 (86–94) 164/18187 (83–91) 219/25187 (81–92) 155/17994 (88–97) 120/12889 (81–94) 79/8984 (74–91) 62/74
  • Data are presented as n or % (95% CI) n/N. Mycobacterium tuberculosis culture positivity was used as the reference standard. PPV: positive predictive value; NPV: negative predictive value. #: only patients with a valid induced sputum smear and culture result are included (fig. 1); : only patients with available HIV results are included (202 patients refused test/HIV status unknown); §: only patients with available CD4 cell count data are included (74 HIV-infected patients missing recent CD4 cell count data); ƒ: p=0.05 between the two patient groups.