Table 3– Association of plasma advanced glycation end-products (AGEs) and autofluorescence (AFR) with forced expiratory volume in 1 s (FEV1) % predicted
Modelβ#95% CIp-value
CML10.4060.256–0.556<0.001
20.4050.249–0.562<0.001
30.5180.352–0.685<0.001
40.5080.316–0.701<0.001
CEL1-0.462-0.608– -0.316<0.001
2-0.464-0.617– -0.312<0.001
3-0.427-0.598– -0.256<0.001
4-0.426-0.624– -0.228<0.001
ln(pentosidine)10.022-0.139–0.1830.790
20.035-0.133–0.2030.679
30.087-0.089–0.2630.331
40.127-0.076–0.3300.218
AFR1-0.443-0.579– -0.307<0.001
2-0.383-0.520– -0.246<0.001
3-0.402-0.556– -0.248<0.001
4-0.400-0.578– -0.222<0.001
  • CML: Nε-(carboxymethyl)lysine; CEL: Nε-(carboxyethyl)lysine. #: increase (in sd) in FEV1 % predicted per sd increase in plasma AGEs or AFR. Model 1: adjusted for age and sex; model 2: model 1 + pack-years; model 3: model 2 + glomerular filtration rate, body mass index, high-density lipoprotein cholesterol and ln(triglycerides); model 4: model 3 + ln(C-reactive protein). n=143.