Subject characteristics | OA | NOA | OC | NOC | p-value |
Subjects n | 74 | 249 | 9 | 29 | |
Age years | 11.1±2.8 | 11.1±3.0 | 12.4±2.2 | 11.8±2.9 | 0.344 |
Females | 47.3 | 38.6¶ | 44.4 | 69.0 | 0.014 |
Height cm | 150.5±15.3+ | 143.8±16.1 | 154.0±12.0 | 151.5±15.9 | 0.001 |
Weight kg | 65.4±24.7¶,+ | 39.1±13.4 | 70.9±18.8¶,+ | 44.1±15.2 | <0.001 |
BMI z-score SDS | 2.1±0.3¶,+ | 0.2±0.9 | 2.1±0.4¶,+ | 0.1±0.8 | <0.001 |
Atopic# yes/no (% yes) | 27/12 (69.2)§ | 42/8 (84.0)¶,§ | 2/7 (22.2) | 14/14 (50.0) | <0.001 |
FEV1 % pred | 96.1±14.1 | 96.3±14.0 | 94.3±12.7 | 97.8±13.1 | 0.908 |
FVC % pred | 100.5±11.2 | 97.4±11.9 | 97.4±12.5 | 97.0±11.8 | 0.581 |
FEV1/FVC % pred | 79.2±6.6¶ | 80.7±8.2¶ | 84.1±4.4 | 88.0±7.8 | <0.001 |
TLC % pred | 106.8±13.3 | 100.3±10.7 | 97.3±9.5 | 99.1±9.3 | 0.568 |
FEV1/TLC# % | 88.5±12.9¶ | 86.5±9.4+ | 96.7±5.3 | 99.1±8.0 | 0.003 |
FRC# % pred | 102.2±23.6 | 116.7±18.7 | 93.5±22.0 | 112.0±16.2 | 0.046 |
ERV# % pred | 86.1±37.1¶ | 112.3±23.7 | 117.8±24.5 | 121.3±27.2 | 0.004 |
RV# % pred | 121.4±50.1§ | 120.9±29.6§ | 64.9±36.0 | 101.1±30.7 | 0.003 |
RV/TLC# % | 24.0±8.0§ | 26.0±7.0§ | 14.0±7.0 | 22.0±0.6 | 0.005 |
Data are presented as mean±sd or %, unless otherwise stated. OA: obese asthma; NOA: nonobese asthma; OC: obese control; NOC: nonobese control; BMI: body mass index; SDS: standard deviation score; FEV1: forced expiratory volume in 1 s; % pred: % predicted; FVC: forced vital capacity; TLC: total lung capacity; FRC: functional residual capacity; ERV: expiratory reserve volume; RV: residual volume. #: data available on a subset of participants only (OA n=31; NOA n=12; OC n=9; and NOC n=15); ¶: versus NOC; +: versus NOA; §: versus OC; p<0.017 for post hoc analyses. Bold indicates statistical significance.