Table 2– A selection of the most highly upregulated and downregulated genes in idiopathic pulmonary fibrosis (IPF) vessels compared to controls
Gene descriptionGene symbolProbe set IDParametric p-valueFDRFold-changeDirection in IPF
Cellular proliferation
 Signal transducer and activator of transcription 1, 91 kDaSTAT1200887_s_at0.00011920.031.8Up
 SPARC-related modular calcium binding 2SMOC2223235_s_at1.83×10−50.012.34Up
 YY1 transcription factorYY1224718_at0.00039990.050.58Down
 Kruppel-like factor 10KLF10202393_s_at0.00016280.030.44Down
 Transforming growth factor-β-induced, 68 kDaTGFBI201506_at1.41×10−50.012.41Up
 Thy-1 cell surface antigenTHY1213869_x_at0.00019630.033.53Up
Wnt signalling
 Secreted frizzled-related protein 2SFRP2223122_s_at0.00040540.059Up
Apoptosis
 Insulin-like growth factor binding protein 3IGFBP3212143_s_at0.00015550.030.29Down
 Homeodomain interacting protein kinase 2HIPK2225368_at0.00024840.040.44Down
 Pim-1 oncogenePIM1209193_at4.39×10−50.020.31Down
Endothelial dysfunction/proliferation
 Plasminogen activator, urokinasePLAU205479_s_at0.00016120.032.29Up
 Sphingosine-1-phosphate receptor 1S1PR1239401_at0.0001340.030.45Down
 Kruppel-like factor 6KLF6224606_at9.92×10−50.030.53Down
Hypoxia-related signalling
 Arginase, type IIARG2203946_s_at0.0001450.030.4Down
 Hypoxia inducible factor 3, α-subunitHIF3A219319_at0.00060360.050.34Down
 Rho-GTPase activating protein 26ARHGAP26205068_s_at8.69×10−50.030.47Down
Complement activation
 Complement component 4AC4A214428_x_at5.8×10−60.012.93Up
 Complement component 4BC4B208451_s_at2.07×10−50.012.71Up
 Complement factor HCFH213800_at0.00028010.043.61Up
Vasoreactivity
 Potassium large conductance calcium-activated channelKCNMB4219287_at0.00064960.050.42Down
 Prostaglandin F2 receptor negative regulatorPTGFRN224937_at3.50×10−50.022.36Up
 Angiotensin II receptor, type 2AGTR2207294_at0.00095390.060.59Down
  • Univariate analysis demonstrated 255 differentially expressed genes between IPF arterioles and controls p<0.001, q<10. A full list is available in the online supplementary material. FDR: false discovery rate; SPARC: secreted protein, acidic, cysteine-rich; YY1: yin and yang protein; Thy-1: thymus cell antigen 1; Pim-1: proviral integration site 1; Rho-GTPase: Rho-guanosine triphosphate hydrolase.