| Autoimmune disease | Adenocarcinoma | Squamous cell carcinoma | Large cell carcinoma | Small cell carcinoma | ||||||||||||||||||
| Observed | SIR (95% CI) | Deaths | Person-yrs | HR (95% CI) | Observed | SIR (95% CI) | Deaths | Person-yrs | HR (95% CI) | Observed | SIR (95% CI) | Deaths | Person-yrs | HR (95% CI) | Observed | SIR (95% CI) | Deaths | Person-yrs | HR (95% CI) | |||
| Addison’s disease | 5 | 1.17 (0.37–2.74) | 4 | 10 | 1.19 (0.44–3.16) | 7 | 1.98 (0.79–4.11) | 6 | 3 | 2.00 (0.90–4.46) | 4 | 1.29 (0.34–3.35) | 4 | 1 | 2.22 (0.83–5.91) | 2 | 1.08 (0.10–3.96) | 2 | 5 | 0.44 (0.11–1.78) | ||
| Amyotrophic lateral sclerosis | 2 | 0.49 (0.05–1.81) | 2 | 2 | 1.65 (0.41–6.59) | 5 | 1.02 (0.32–2.40) | 3 | 3 | 1.04 (0.33–3.21) | 9 | 2.27 (1.03–4.32) | 9 | 6 | 1.12 (0.58–2.14) | 3 | 1.61 (0.30–4.76) | 3 | 0.1 | 5.49 (1.77–17.05) | ||
| Ankylosing spondylitis | 11 | 0.78 (0.39–1.39) | 6 | 14 | 0.79 (0.35–1.75) | 16 | 1.23 (0.70–2.01) | 10 | 15 | 1.29 (0.69–2.39) | 14 | 1.26 (0.69–2.13) | 13 | 6 | 1.51 (0.88–2.61) | 7 | 1.12 (0.44–2.31) | 7 | 5 | 1.05 (0.50–2.20) | ||
| Behcet’s disease | 8 | 1.22 (0.52–2.42) | 7 | 20 | 0.73 (0.35–1.54) | 7 | 1.07 (0.42–2.21) | 4 | 19 | 0.59 (0.22–1.56) | 7 | 1.30 (0.51–2.69) | 6 | 15 | 0.79 (0.35–1.76) | 4 | 1.34 (0.35–3.47) | 4 | 5 | 0.59 (0.22–1.57) | ||
| Coeliac disease | 5 | 0.83 (0.26–1.95) | 0 | 8 | 8 | 1.72 (0.73–3.40) | 6 | 40 | 0.48 (0.22–1.08) | 5 | 1.19 (0.37–2.79) | 3 | 6 | 0.57 (0.18–1.76) | 3 | 1.15 (0.22–3.39) | 3 | 3 | 0.62 (0.20–1.92) | |||
| Chronic rheumatic heart disease | 32 | 0.99 (0.67–1.39) | 24 | 76 | 1.05 (0.71–1.57) | 55 | 1.46 (1.10–1.90) | 43 | 78 | 0.98 (0.72–1.32) | 26 | 0.86 (0.56–1.26) | 20 | 53 | 0.77 (0.50–1.20) | 25 | 1.63 (1.05–2.41) | 25 | 9 | 1.70 (1.14–2.51) | ||
| Crohn’s disease | 46 | 1.31 (0.96–1.75) | 34 | 99 | 0.97 (0.69–1.36) | 35 | 1.43 (0.99–1.98) | 28 | 59 | 1.06 (0.73–1.54) | 28 | 1.20 (0.80–1.73) | 26 | 17 | 1.28 (0.87–1.88) | 22 | 1.51 (0.94–2.29) | 21 | 12 | 1.16 (0.75–1.78) | ||
| Discoid lupus erythematosus | 9 | 4.55 (2.06–8.67) | 8 | 6 | 1.46 (0.73–2.92) | 5 | 3.22 (1.02–7.58) | 3 | 17 | 0.42 (0.14–1.31) | 10 | 6.86 (3.27–12.66) | 10 | 19 | 1.02 (0.55–1.89) | 6 | 7.36 2.65–16.12) | 6 | 2 | 2.83 (1.28–6.28) | ||
| Graves’ disease/hyperthyroidism | 93 | 1.19 (0.96–1.46) | 68 | 168 | 0.86 (0.68–1.10) | 66 | 1.25 (0.97–1.59) | 51 | 107 | 0.92 (0.70–1.21) | 73 | 1.37 (1.07–1.72) | 70 | 59 | 1.09 (0.87–1.38) | 55 | 1.73 (1.30–2.25) | 51 | 51 | 0.91 (0.69–1.20) | ||
| Hashimoto’s disease/hypothroidism | 17 | 0.89 (0.52–1.43) | 12 | 33 | 1.22 (0.70–2.16) | 14 | 0.98 (0.54–1.65) | 10 | 22 | 0.90 (0.49–1.68) | 22 | 1.66 (1.04–2.52) | 19 | 24 | 0.77 (0.49–1.20) | 10 | 1.19 (0.57–2.20) | 8 | 32 | 0.65 (0.33–1.30) | ||
| Immune thrombocytopaenic purpura | 7 | 2.14 (0.85–4.44) | 4 | 6 | 0.72 (0.27–1.91) | 3 | 1.23 (0.23–3.65) | 0 | 0 | 3 | 1.34 (0.25–3.98) | 2 | 11 | 0.62 (0.15–2.47) | 3 | 2.19 (0.41–6.47) | 3 | 1 | 2.67 (0.86–8.29) | |||
| Localised scleroderma | 5 | 2.51 (0.79–5.91) | 5 | 3 | 2.09 (0.87–5.00) | 4 | 3.05 (0.79–7.88) | 4 | 3 | 1.66 (0.62–4.43) | 2 | 1.60 (0.15–5.88) | 1 | 0.2 | 2.41 (0.34–17.11) | 0 | ||||||
| Multiple sclerosis | 23 | 1.00 (0.63–1.51) | 17 | 16 | 1.54 (0.96–2.48) | 16 | 0.96 (0.55–1.56) | 12 | 20 | 1.11 (0.63–1.95) | 15 | 0.90 (0.50–1.50) | 15 | 10 | 1.39 (0.84–2.30) | 7 | 0.75 (0.30–1.54) | 7 | 2 | 2.22 (1.06–4.65) | ||
| Myasthenia gravis | 2 | 0.41 (0.04–1.52) | 1 | 6 | 0.43 (0.06–3.05) | 3 | 0.67 (0.13–2.00) | 1 | 21 | 0.22 (0.03–1.53) | 7 | 1.92 (0.76–3.99) | 7 | 4 | 1.56 (0.74–3.28) | 5 | 2.28 (0.72–5.37) | 5 | 6 | 0.64 (0.27–1.54) | ||
| Pernicious anaemia | 6 | 0.40 (0.14–0.88) | 2 | 0.3 | 2.15 (0.54–8.52) | 11 | 0.59 (0.29–1.05) | 8 | 19 | 0.66 (0.33–1.32) | 12 | 0.83 (0.42–1.45) | 11 | 5 | 1.34(0.74–2.43) | 7 | 0.94 (0.37–1.96) | 7 | 4 | 0.87 (0.42–1.83) | ||
| Polymyalgia rheumatic | 63 | 1.14 (0.87–1.45) | 50 | 128 | 0.95 (0.72–1.26) | 46 | 0.98 (0.72–1.30) | 38 | 63 | 1.12 (0.82–1.54) | 41 | 1.06 (0.76–1.44) | 38 | 17 | 1.51 (1.10–2.07) | 26 | 1.00 (0.65–1.47) | 21 | 30 | 0.67 (0.44–1.03) | ||
| Polymyositis/dermatomyositis | 13 | 3.68 (1.95–6.31) | 10 | 13 | 1.03 (0.56–1.92) | 12 | 3.94 (2.02–6.90) | 9 | 8 | 0.99 (0.51–1.90) | 15 | 5.56 (3.10–9.19) | 13 | 13 | 1.36 (0.79–2.34) | 7 | 4.53 (1.79–9.38) | 6 | 6 | 1.02 (0.46–2.27) | ||
| Primary biliary cirrhosis | 1 | 0.33 (0.00–1.91) | 0 | 0 | 9 | 5.10 (2.31–9.73) | 7 | 21 | 0.72 (0.34–1.51) | 1 | 0.58 (0.00–3.32) | 1 | 0.2 | 4.67 (0.67–32.63) | 1 | 0.77 (0.00–4.40) | 1 | 0.2 | 2.65 (0.37–18.88) | |||
| Psoriasis | 48 | 1.23 (0.91–1.63) | 29 | 90 | 0.73 (0.50–1.05) | 63 | 1.71 (1.31–2.19) | 53 | 78 | 1.05 (0.80–1.38) | 49 | 1.58 (1.17–2.09) | 42 | 19 | 1.39 (1.02–1.88) | 35 | 2.00 (1.39–2.79) | 32 | 20 | 1.21 (0.86–1.72) | ||
| Rheumatic fever | 24 | 2.55 (1.63–3.80) | 17 | 50 | 0.65 (0.41–1.05) | 21 | 2.06 (1.28–3.16) | 17 | 38 | 0.79 (0.49–1.27) | 8 | 0.99 (0.42–1.96) | 7 | 7 | 0.84 (0.40–1.76) | 7 | 1.60 (0.63–3.31) | 7 | 8 | 0.74 (0.35–1.54) | ||
| Rheumatoid arthritis | 152 | 1.17 (0.99–1.37) | 121 | 185 | 1.05 (0.88–1.26) | 192 | 1.71 (1.48–1.97) | 153 | 318 | 0.97 (0.83–1.14) | 143 | 1.41 (1.19–1.67) | 121 | 102 | 1.11 (0.93–1.33) | 91 | 1.60 (1.29–1.97) | 85 | 85 | 1.06 (0.86–1.32) | ||
| Sarcoidosis | 28 | 1.19 (0.79–1.72) | 23 | 33 | 1.35 (0.90–2.03) | 21 | 1.10 (0.68–1.69) | 18 | 60 | 0.97 (0.61–1.54) | 20 | 1.15 (0.70–1.77) | 19 | 11 | 1.50 (0.96–2.36) | 15 | 1.49 (0.83–2.46) | 14 | 11 | 1.10 (0.65–1.86) | ||
| Systemic lupus erythematosus | 23 | 2.12 (1.34–3.18) | 21 | 20 | 1.32 (0.86–2.03) | 22 | 2.97 (1.86–4.50) | 16 | 37 | 0.92 (0.56–1.50) | 19 | 2.55 (1.53–3.99) | 18 | 13 | 0.99 (0.62–1.57) | 15 | 3.38 (1.89–5.59) | 15 | 6 | 2.25 (1.36–3.74) | ||
| Systemic sclerosis | 32 | 2.98 (2.03–4.21) | 23 | 44 | 1.15 (0.76–1.73) | 27 | 2.54 (1.68–3.71) | 25 | 43 | 1.19 (0.80–1.76) | 12 | 1.36 (0.70–2.38) | 9 | 8 | 0.88 (0.46–1.69) | 8 | 1.63 (0.70–3.23) | 5 | 9 | 0.87 (0.36–2.08) | ||
| Ulcerative colitis | 49 | 0.99 (0.73–1.30) | 40 | 95 | 1.09 (0.80–1.49) | 34 | 0.85 (0.59–1.20) | 28 | 99 | 0.75 (0.52–1.09) | 32 | 0.90 (0.62–1.28) | 28 | 30 | 0.97 (0.67–1.40) | 18 | 0.84 (0.50–1.33) | 14 | 26 | 0.88 (0.52–1.50) | ||
| Granulomatosis with polyangiitis | 22 | 0.88 (0.55–1.34) | 17 | 15 | 1.10 (0.68–1.76) | 32 | 1.16 (0.80–1.64) | 26 | 36 | 1.09 (0.74–1.60) | 30 | 1.37 (0.92–1.96) | 25 | 14 | 1.24 (0.84–1.83) | 6 | 0.51(0.18–1.12) | 6 | 2 | 2.09 (0.94–4.67) | ||
| All | 741 | 1.20 (1.11–1.28) | 557 | 1153 | 0.99 (0.91–1.08) | 740 | 1.40 (1.30–1.50) | 582 | 1240 | 0.94 (0.86–1.02) | 615 | 1.31 (1.21–1.42) | 544 | 475 | 1.13 (1.04–1.23) | 388 | 1.43 (1.29–1.58) | 357 | 348 | 1.03 (0.93–1.15) | ||
Data are presented as n, unless otherwise specified. Bold indicates that the 95% CI does not include 1.00.