Table 1– Patient characteristics at the time of diagnosis of interstitial lung disease in combined variable immunodeficiency disorder associated with granulomatous disease (GD)

Patient	Sex/ethnicity	Recurrent infections	Autoimmune disorder	Respiratory symptoms	Auscultation	Extrathoracic involvement of GD
1	M/c	N	N	D	Crackles	Skin
2	M/c	N	N	N	Crackles	Liver, spleen
3	M/b	N	N	N	n	Spleen, pLN, aLN
4	F/c	Y	N	D	ND	Spleen, aLN
5	M/c	Y	N	N	n	Liver, spleen, aLN, BM
6	F/c	N	Thrombocytopenia, anaemia	N	n	Spleen, aLN
7	F/c	Y	N	N	n	Skin, pLN
8	M/c	Y	N	D, C	n	Liver, spleen, eyes, PFNP
9	M/c	N	N	D	Crackles	Liver, spleen
10	F/c	Y	Biermer’s anaemia, Hashimoto’s thyroiditis	D, C	Crackles	Liver, spleen, pLN, aLN, parotitis
11	F/c	Y	Sicca syndrome	D	Crackles	Spleen
12	F/c	Y	Thrombocytopenia	D, C	Crackles	Liver, spleen
13	M/c	Y	Neutropenia	D, C	Crackles	Liver, spleen
14	M/c	Y	N	N	n	Spleen, eyes, parotitis, CNS
15	M/c	Y	Lupus	N	ND	Liver, spleen, aLN
16	M/b	Y	N	N	n	Spleen, pLN
17	M/c	Y	Anaemia, neutropenia	D	Crackles	None
18	F/c	Y	N	D, C	Crackles	Spleen, skin, aLN
19	F/c	N	Thrombocytopenia	D	n	Liver, spleen, eyes, CNS
20	F/c	N	N	N	n	Spleen

M: male; F: female; c: Caucasian; b: black; N: no; Y: yes; D; dyspnoea; C: cough; n: normal; ND: not determined; p: peripheral; LN: lymph node; a: abdominal; BM: bone marrow; PFNP: peripheral facial nerve paralysis; CNS: central nervous system.