Age yrs | 62.9 (57.0–68.0) |
Males/females n | 96/14 |
Current smokers % | 63 |
Smoking exposure pack-yrs | 41.8 (31.2–54.8) |
Body mass index kg·m−2 | 25.3 (22.4–27.8) |
Methacholine PC20 mg·mL−1 geometric mean (interquartile range) | 1.8 (0.2–2.4) |
FEV1# % pred | 64.2 (57.1–69.3) |
FVC# % pred | 99.0 (91.3–109.9) |
FEV1/IVC# % | 45.2 (39.3–52.7) |
RV/TLC# % pred | 125.6 (112.6–140.3) |
IC % pred | 72.1 (62.7–83.9) |
TL,CO/VA % pred | 74.4 (57.7–90.0) |
Blood % leukocytes | |
Neutrophils | 59.2 (52.3–66.3) |
Eosinophils | 2.2 (1.1–3.3) |
Monocytes | 8.7 (7.4–10.1) |
Basophils | 0.5 (0.3–0.8) |
Lymphocytes | 28.2 (22.3–34.4) |
Sputum ×104 cells·mL−1¶ | |
Total cells | 2.4 (2.1–2.6) |
Macrophages | 1.5 (1.3–1.8) |
Lymphocytes | 0.50 (0.3–0.9) |
Neutrophils | 2.0 (1.7–2.4) |
Eosinophils | 0.4 (0.1–0.7) |
Bronchial epithelial cells | 0.4 (0.2–0.6) |
Bronchial biopsies cells per 0.1 mm2¶ | |
Macrophages | 1.0 (0.8–1.1) |
Neutrophils | 0.6 (0.3–0.9) |
Eosinophils | 0.4 (0.2–0.7) |
CD4+ cells | 1.7 (1.4–1.9) |
CD8+ cells | 1.3 (1.1–1.6) |
Mast cells | 1.4 (1.3–1.5) |
Data are expressed as median (interquartile range), unless otherwise stated. PC20: provocative concentration causing a 20% fall in FEV1; FEV1: forced expiratory volume in 1 s; % pred: % predicted; FVC: forced vital capacity; IVC: inspiratory vital capacity; RV: residual volume; TLC: total lung capacity; IC: inspiratory capacity; TL,CO: transfer factor of the lung for carbon monoxide; VA: alveolar volume. #: post-bronchodilator; ¶: log transformed.