Table 1– Characteristics of wheeze phenotype at age 18 yrs
Non-wheezeUndiagnosed wheezeAsthma
Demographics
 Female sex49 (493/1008)59 (38/64)55 (128/234)
  p-valueRef.0.30.33
 Low social class#32 (292/909)42 (22/53)35 (74/212)
  p-valueRef.0.481
 Family history of asthma43 (419/966)61 (36/59)62 (139/226)
  p-valueRef.0.02<0.001
 Still in education at age 18 yrs71 (699/990)59 (36/61)70 (161/230)
  p-valueRef.0.181
 In work at age 18 yrs68 (675/991)66 (40/61)69 (158/230)
  p-valueRef.11
Atopy, FeNO and self-rated health status
 Atopy at 18 yrs34 (221/643)38 (17/45)69 (114/165)
  p-valueRef.1<0.001
 Atopy at 10 yrs20 (145/731)23 (11/47)57 (104/184)
  p-valueRef1<0.001
 Atopy at 4 yrs14 (99/703)25 (10/40)43 (68/159)
  p-valueRef.0.18<0.001
FeNO ppb+ at 18 yrs17 (425)18 (24)31 (107)
  p-valueRef.1<0.001
 Self-rated health status VAS§81 (932)72 (60)75 (216)
  p-valueRef.<0.001<0.001
  • Data are presented as % (n/N) unless otherwise stated. Comparison of wheeze groups by Chi-squared test for categorical variables determined at p<0.05, group-wise significance adjusted for multiple comparisons. FeNO: exhaled nitric oxide fraction; VAS: visual analogue score. #: low social class categories (IIIM–V); : parent or sibling history of asthma recorded at birth; +: geometric mean (n); §: low scores infer lower self-rated health status (n in parentheses).