Parameter | HR (95% CI) | p-value |
Univariate Cox analysis | ||
Age | 0.991 (0.941–1.045) | 0.749 |
Male | 0.549 (0.220–1.373) | 0.203 |
Body mass index | 0.984 (0.886–1.092) | 0.758 |
FVC % pred | 0.987 (0.966–1.007) | 0.187 |
FEV1 % pred | 0.995 (0.973–1.017) | 0.646 |
DL,CO % pred | 1.002 (0.962–1.044) | 0.918 |
TLC % pred | 0.981 (0.946–1.017) | 0.299 |
LVEF % | 0.989 (0.921–1.061) | 0.752 |
RVSP mmHg | 1.005 (0.966–1.045) | 0.824 |
mPpa mmHg | 1.080 (1.013–1.152) | 0.033 |
PH | 5.201 (1.987–13.61) | <0.001 |
Occurrence of acute exacerbation# | 4.037 (1.568–10.40) | 0.004 |
Multivariate Cox analysis | ||
PH | 4.749 (1.278–17.64) | 0.021 |
Occurrence of acute exacerbation# | 2.924 (1.089–7.852) | 0.055 |
mPpa | 0.989 (0.898–1.090) | 0.827 |
FVC: forced vital capacity; % pred: % predicted; FEV1: forced expiratory volume in 1 s; DL,CO: diffusing capacity of the lung for carbon monoxide; TLC: total lung capacity; LVEF: left ventricular ejection fraction; RVSP: right ventricular systolic pressure; mPpa: mean pulmonary arterial pressure; PH: pulmonary hypertension. #: overall occurrence during follow-up period.