Table 2– Clinical characteristics of 12 patients with multidrug-resistant/extremely drug-resistant tuberculosis (TB) treated with linezolid in Sondalo, Italy
Patient IDDrug resistance profileAnti-TB regimenSputum smear conversion daysSputum culture conversion daysLinezolid exposure daysAdverse events
1H, R, EMB, ETHAMK, LZD, MFX, PZA, TER254744
2H, R, S, EMB, PZA, FQ, ETH, AMK, KMAM, CLOF, LEVO, LZD, MRP, TER5412077Anaemia, leukopenia
3H, R, S, EMB, PZA, CSAMK, ETH, LZD, MFX, MRP, PAS5No conversion50
4H, R, S, EMB, FQ, ETH, AMK, CM, KMAM, CLOF, CS, LZD, MFX, MRP, PZA2338110
5H, R, PZA, FQ, ETH, PAS, CMAM/Cl, AMK, CS, ETH, LZD, MFX, MRP35No conversion50
6H, R, S, EMB, FQ, ETH, AMK, PAS, CM, KMAM, CLOF, LZD, MFX, MRP, PZA7495174
7H, R, S, EMB, PZA, ETH, PAS, KMAM, AMK, CLOF, CS, LZD, MFX, MRP467083
8H, R, S, PZA, FQ, ETH, PAS, KMAM, AMK, CLOF, CS, EMB, LZD, MRP344490
9H, R, S, EMB, PZA, CS, PAS, KMAM, AMK, ETH, LZD, MRP, TER223720Low platelets (LZD temporary interruption)
10H, R, S, PZA, FQ, PASAMK, EMB, ETH, LZD, MFX, TER528420Neuropathy (LZD temporary interruption)
11H, R, S, EMB, PZA, PASAM, AMK, ETH, LZD, MFX, MRP147No conversion30
12H, R, S, EMB, PZA, FQ, ETH, CS, PASAM, AMK, CLOF, ETH, LZD, MFX, MRP, PZA139150120Neuropathy
  • AM: amoxicillin; AM/Cl: amoxicillin/clavulanate acid; AMK: amikacin; CLOF: clofazimine; CM: capreomycin; CS: cycloserine; EMB: ethambutol; ETH: ethionamide; FQ: any fluoroquinolone; H: isoniazid; KM: kanamycin; LEVO: levofloxacin; LZD: linezolid; MFX: moxifloxacin; MRP: meropenem; PAS: p-aminosalicylic acid; PZA: pyrazinamide; R: rifampicin; S; streptomycin; TER: terizidone.