PT  - JOURNAL ARTICLE
AU  - Friedrich Grimminger
AU  - Andreas Günther
AU  - Carlo Vancheri
TI  - The role of tyrosine kinases in the pathogenesis of idiopathic pulmonary fibrosis
AID  - 10.1183/09031936.00149614
DP  - 2015 May 01
TA  - European Respiratory Journal
PG  - 1426--1433
VI  - 45
IP  - 5
4099  - http://erj.ersjournals.com/content/45/5/1426.short
4100  - http://erj.ersjournals.com/content/45/5/1426.full
SO  - Eur Respir J2015 May 01; 45
AB  - Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with a median survival time from diagnosis of 2–3 years. Although the pathogenic pathways have not been fully elucidated, IPF is believed to be caused by persistent epithelial injury in genetically susceptible individuals. Tyrosine kinases are involved in a range of signalling pathways that are essential for cellular homeostasis. However, there is substantial evidence from in vitro studies and animal models that receptor tyrosine kinases, such as the platelet-derived growth factor receptor, vascular endothelial growth factor receptor and fibroblast growth factor receptor, and non-receptor tyrosine kinases, such as the Src family, play critical roles in the pathogenesis of pulmonary fibrosis. For example, the expression and release of tyrosine kinases are altered in patients with IPF, while specific tyrosine kinases stimulate the proliferation of lung fibroblasts in vitro. Agents that inhibit tyrosine kinases have shown anti-fibrotic and anti-inflammatory effects in animal models of pulmonary fibrosis. Recently, the tyrosine kinase inhibitor nintedanib has shown positive results in two phase III trials in patients with IPF. Here, we summarise the evidence for involvement of specific tyrosine kinases in the pathogenesis of IPF and the development of tyrosine kinase inhibitors as treatments for IPF. Tyrosine kinases have been implicated in the pathogenesis of fibrosis and are a target for the treatment of IPF http://ow.ly/G71aI