TY - JOUR T1 - Lung recruitment maneuver with and without nebulized albuterol for acute lung injury JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P4893 AU - Mohamed Badawy AU - Salah Asida Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P4893.abstract N2 - Background : β2-Adrenoceptor agonists accelerate resolution of pulmonary edema in experimental and clinical studies. We tested the hypothesis that nebulized albuterol when combined with lung recruitment maneuver would improve oxygenation in patients with acute lung injury (ALI) and /or acute respiratory distress syndrome (ARDS) during mechanical ventilation and accelerate resolution of pulmonary edema. Patients and Methods: A randomized controlled study of50 patients admitted to the ICU for ALI and /or ARDS. They were assigned to two groups and subjected to lung recruitment maneuver by increasing peak airway pressure 10 cm water above the lower infliction point of the pressure volume curve or above the pre-recruitment PEEP level for 10 minutes. In albuterol group :(25 cases) albuterol was nebulized through the endotracheal tube while in the control group (25 cases )10 ml saline ( placebo ) were nebulized instead of albuterol. This regimen was repeated every 8 hours for 3 days. Alveolar fluid samples were withdrawn before lung recruitment and one hour after recruitment with albuterol ( or saline ) nebulization for protein concentration measurement in the alveolar fluid. Results : we found significant difference between the two groups regarding PaO2 ( P=0.003) and PaO2/ FiO2 ( P= 0.023) . No significant difference was found regarding alveolar fluid clearance and alveolar protein concentration. Conclusion: nebulised albuterol improved oxygenation but not alveolar fluid clearance when combined with lung recruitment in ALI or ARDS. ER -