TY - JOUR T1 - Symptoms and comorbidities associated with restrictive spirometry JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P4759 AU - Berne Eriksson AU - Anne Lindberg AU - Eva Rönmark AU - Bo Lundbäck Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P4759.abstract N2 - Introduction The diagnosis of restrictive lung diseases requires static spirometry. However, dynamic spirometry can identify subjects with a restrictive pattern. Few studies have investigated comorbidity and risk-factor pattern for subjects with a restrictive spirometric pattern.Aim To investigate the risk-factors and comorbidities associated with a restrictive spirometric pattern.Method A random sample of middle aged and elderly from the general population, n=1,563, mean age 61 y (34-85) participated in pulmonary function tests and structured interviews. A restrictive spirometric pattern was defined as a FEV1/(F)VC≥0.70 and the highest value of FVC or SVC (slow vital capacity)<80% of pred. The group with a restrictive spirometric pattern was compared those with normal spirometry. All analyses were adjusted for sex and age.Results The prevalence of restrictive spirometric pattern was 9.7% (men 10.0%; women 9.4%). Characteristics for restriction included higher BMI, previous tuberculosis and rheumatic disease, all possible causative associations. The restrictive group had a significantly increased risk of having respiratory symptoms, such as cough, chronic bronchitis and dyspnoea. Heart disease, myocardial infarction and claudication were significantly more common in the restrictive group, OR 1.5 (CI 1.1-2.3); OR 2.5(CI 1.4-4.7); OR 3.1 (CI 1.4-6.4). Non-significantly higher OR:s were found for hypertension, angina and diabetes. Smoking habits did not differ from the normal group.Conclusion Restrictive spirometric pattern is common in middle age and elderly and is associated with respiratory symptoms and cardiovascular comorbidities, but not with smoking, when compared to subjects with normal lung function. ER -