PT  - JOURNAL ARTICLE
AU  - Helena Backman
AU  - Caroline Stridsman
AU  - Linnea Hedman
AU  - Sven-Arne Jansson
AU  - Anne Lindberg
AU  - Eva Rönmark
AU  - Bo Lundback
TI  - Restrictive pattern of lung function in the general adult population of northern Sweden
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P4758
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P4758.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P4758.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Background Restrictive lung function is defined as reduced lung expansion expressed as a decreased total lung capacity. Attempts have been made to use dynamic spirometry to define restrictive patterns of lung function, and studies such as the NHANES and Tucson studies have reported high prevalence of restriction.Aim To estimate the prevalence of restrictive spirometric pattern among adults in northern Sweden.Methods In 2008-2009 a general population sample aged 22-81y from northern Sweden was examined by structured interview and spirometry, and 726 subjects participated (71% of invited). Restrictive pattern was defined as post bronchodilator 1) FVC<80% of predicted and FEV1/FVC>LLN 5%, 2) FVC<LLN 5% and FEV1/FVC>LLN 5%, and 3) FVC<80% of predicted and FEV1/FVC>0.7. The GLI reference equations were used. Demographic and environmental risk factors were calculated by uni-variate and multiple logistic regression analyses.Results According to model 1), the prevalence of restrictive spirometric pattern was 2.9%, to model 2) 2.1%, and 3) 2.5%, with no significant gender difference. According to model 1), the prevalence was 4.0% in ages >60y vs. 2.3% in ages ≤60y, p=0.18. By socio-economic status, the prevalence was highest among manual workers in industry, 5.8%, p=0.02 vs. all others. The prevalence among ever smokers was 3.4% vs. 2.4% in never smokers (ns). In risk analyses, no other significant association except the risk of being a manual worker in industry was found.Conclusions The prevalence on population level of restrictive spirometric pattern was low, 2-3%. Manual workers in industry were associated with an increased risk, and no other significant risk factors were found.