PT  - JOURNAL ARTICLE
AU  - Lioubov Shpagina
AU  - Mikhail Voevoda
AU  - Olga Kotova
AU  - Vladimir Maksimov
AU  - Ilya Shpagin
AU  - Pavel Orlov
AU  - Oksana Gerasimenko
TI  - Genetic variability and occupational chronic obstructive pulmonary disease in subjects exposed to different environmental factors
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P4790
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P4790.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P4790.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Background. Chronic obstructive pulmonary disease (COPD) is a severe lung disease with high prevalence and mortality, caused by noxious particles including occupational dusts and fumes. Genetic features of COPD due to different occupational factors are not enough studied.Objective is to investigate the association of single nucleotide polymorphisms (SNPs) rs 1800470 transforming growing factor β1 (TGF β1) gene, rs 1828591 hedgehog interacting protein (HHIP) gene, rs 4129267 interleukin 6 receptor (IL-6R) gene, rs 1051730 nicotinic acetylcholine receptor 3 (CHRNA 3) gene with COPD in subjects who exposed to different occupational risk factors.Methods. Fifty two COPD subjects exposed to dusts and 30 exposed to aromatic series hydrocarbons fume enrolled. Control group – 105 healthy donors. Associations were modeled using logistic regression.Results. SNP rs 1828591 was associated with COPD both in subjects exposed to dusts and in those exposed to chemicals. In the group exposed to dusts, for genotypes AA and AG OR = 2.22, 95 % CI = 1.01–4.91 and OR = 2.05, 95 % CI = 1.03 – 4.06, respectively. In the group exposed to chemicals, for genotype AG OR = 0.17, 95 % CI = 0.04 – 0.70, for genotype GG OR = 5.10, 95 % CI = 1.15 – 17.12. SNP rs 1800470 was associated with COPD in subjects exposed to dusts only. For genotypes AA and AG OR = 0.34, 95 % CI = 0.15 – 0.72 and OR = 0.4, 95 % CI = 0.2 – 0.8, respectively. SNPs rs 4129267 and rs 1051730 was not associated with occupational COPD.Conclusions. Occupational COPD due to dusts is associated with SNP rs1800470 and SNP rs1828591. Occupational COPD due to chemicals is associated with SNP rs1828591.