TY - JOUR T1 - FEV<sub>1</sub> dynamics and total NO<sub>3</sub>-/ NO<sub>2</sub>- level in exhaled breath condensate of current smokers JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P4197 AU - Elena Zaprudnova AU - Svetlana Soodaeva AU - Igor Klimanov AU - Timur Li AU - Natalia Popova AU - Nailya Kubysheva AU - Lidiya Nikitina AU - Fedor Petrovskiy Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P4197.abstract N2 - The study aim was to investigate pre- and post-exercise FEV1 level and the level of total NO3-/ NO2- in exhaled breath condensate (EBC) in smokers compared to non-smokers.The control group included healthy non-smokers aged 18 - 35 years (those with no diagnosed respiratory diseases). The second group included current smokers aged 18 - 35 years (smoking history of ≥ 3 years) without respiratory pathology. Both groups were studied at rest, post-exercise FEV1 level was also measured after 10 minutes jogging.The 1.6-fold reduced basal level of NO metabolites in EBC was found in smokers compared to non-smokers (1,42 ± 0,11 mkmol/l and 2,4 ± 0,26 mkmol/l respectively, p &lt;0.05). Significant differences in post-exercise FEV1 level in smokers and non-smokers were not observed probably due to the small smoking history. Nevertheless, post-exercise FEV1 level in smokers was 1.3-fold lower than in non-smoking group.Thus, in healthy smokers the reduced respiratory functional capacity was found to be associated with impaired NO synthesis in the lungs even at relatively small smoking history. ER -