TY - JOUR T1 - Hydrogen sulphide as a biomarker in COPD and asthma JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P3983 AU - Debraj Jash AU - Debraj Jash Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P3983.abstract N2 - Background:Exhaled NO, H2S and CO was extensively studied as biomarkers in asthma and COPD. Recent studies proposed role of serum H2S as a biomarker in different obstructive airway diseases. Evaluation of the association of serum H2S level to COPD and asthma (both in stable state and during exacerbation) was done in our study.Materials &Methods:We measured serum levels of H2S, spirometry, ell differential counts in induced sputum in 25patients with acute exacerbation of COPD (AECOPD), 65 patients with stable COPD,32 patients with acute exacerbation of asthma,50 patients of controlled asthma and 60 healthy subjects. We studied the relation of serum H2S with age, sex, smoking, FEV1, sputum differential count.Results:There was no significant difference in serum H2S level between in relation to age and sex among normal population but there was significant difference among smokers and non-smokers. Serum H2S was significantly lower(p < 0.01) in COPD and asthma subjects compared to normal population. Serum H2S was lower in COPD than asthma but there was no significant difference between them. Serum H2S level was significantly higher in patients with stable COPD and controlled asthma than in patients with exacerbations of COPD and in acute exacerbations of asthma. Serum H2S level was correlated positively with FEVI in patients with COPD (r=0.35) and asthma (r= 0.26). Serum H2S level was negatively correlated with proportion of neutrophils in sputum (r = - 0.45 in COPD and r = 0.34 in asthma) and positively correlated with proportion of lymphocytes (r = 0.39 in COPD and r = 0.32 in asthma).Conclusion:Serum H2S may serve as a biomarker in exacerbation of COPD and asthma but more studies are required to arrive at a definite conclusion. ER -