PT  - JOURNAL ARTICLE
AU  - Lubov Novikova
AU  - Yulia Ilkovich
AU  - Dali Dzadzua
AU  - Natalia Korzina
TI  - Pregnancy course in patients with interstitial lung diseases
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P3763
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P3763.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P3763.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - It is known that pregnancy may have a positive influence on the course of sarcoidosis, and, on the contrary, it may worsen the course of lymphangioleiomyomatosis. There is few information concerning influence of pregnancy on other interstitial lung diseases (ILD).We observed pregnancy in 11 women with ILD. 4 of them had nonspecific interstitial pneumonia (NsIP), 5 - langerhans cell histiocytosis (LCH), and 2 - hypersensitive pneumonitis (HP). The mean age of patients was 29,9±6,8 years (19-41 years). 6 women continued glucocorticosteroid intake during pregnancy (2,5-10 mg of prednisolonum per day); 3 patients stopped cytostatic intake.2 women had physiologic delivery, 6 - cesarean section, 3 patients (2 with NsIP, 1 with LCH) had medical abortion due to progressing respiratory failure. Seven of eight newborns were healthy, one had congenital heart valve defect (mother with LCH). In all NsIP patients disease progressing after pregnancy was observed. In one woman with HP exacerbation of the disease was observed soon after delivery. Another patient with HP had favorable course of disease after pregnancy. 2 of 5 LCH patients had quite favorable course of pregnancy and birth, one had spontaneous pheumothorax on 38th week of pregnancy, and in 2 cases disease progression after delivery was observed.Conclusion: pregnancy in ILD is associated with increased risk of adverse events and leads to disease progression in most cases.