PT  - JOURNAL ARTICLE
AU  - Cláudia Guerreiro
AU  - Elisabete Patricio
AU  - Paula Viegas
AU  - Teresa Salgado
AU  - Isabel Ruivo
AU  - Ulisses Brito
TI  - Ventilatory changes induced by obesity
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P3542
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P3542.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P3542.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Introduction:Obesity is responsible for changes in respiratory mechanics.Bariatric surgery reduces the impact of co-morbidities associated with obesity.Objectives:To evaluate the effect of obesity on lung function using pulmonary function testing (PFT)and arterial blood gases(ABG).Methods:We conducted a prospective and comparative study of pulmonary function and gas exchange before and after bariatric surgery.Results:During the study period,73 patients underwent bariatric surgery.Of these,59 agreed to repeat the PFT after the procedure.From those,81.4% were female.The average age was 44.8±11.4 years.Forty-eight subjects (81.4%) had a BMI> 40Kg/m2 before surgery.All patients underwent spirometry,55 patients were also evaluated with ABG and 18 had done plethysmography.At baseline,35.6% had normal PFT.The most frequent change was the reduction of the Maximal Expiratory Flow at 25% of Forced Vital Capacity(MEF25)in 61% of cases.Twenty nine percent had hypoxemia prior to surgery.Regarding spirometric evaluation we found an average increase of:241±300ml in Forced Vital Capacity (p<0,0001);296±242ml in Forced Expiratory Volume at the first second (p<0,0001);461±986ml in Peak Expiratory Flow(p=0.001) as well as in MEF25,50 and 75 with an average increase of 438ml, 508ml and 481ml respectively (p<0.0001)after surgery.These changes were accompanied by an average increase of 6.27±15.56 mmHg in partial pressure of oxygen,as well as an average increase of 146±340ml in Expiratory Reserve Volume (p=0.001).It was shown that there is a positive correlation between weight loss and increase in FEV1, MEF50 and MEF25.Conclusion:Although 93% of our sample still maintains BMI ≥25Kg/m2 there was a significant improvement in pulmonary function and gas exchange.