PT - JOURNAL ARTICLE AU - Takashi Motegi AU - Takeo Ishii AU - Kumiko Hattori AU - Yuji Kusunoki AU - Ryuko Furutate AU - Akihiko Gemma AU - Kozui Kida TI - Determination of the existence of a correlation between lung function decline and changes in the COPD assessment test DP - 2014 Sep 01 TA - European Respiratory Journal PG - P3587 VI - 44 IP - Suppl 58 4099 - http://erj.ersjournals.com/content/44/Suppl_58/P3587.short 4100 - http://erj.ersjournals.com/content/44/Suppl_58/P3587.full SO - Eur Respir J2014 Sep 01; 44 AB - Background: COPD assessment test (CAT) is used to ascertain the health status of patients with COPD. Although the clinical factors related to CAT score changes have been researched, there are few reports on the relationship between changes in the forced expired volume in 1 s (FEV1) and the CAT. Aims: To determine whether annual FEV1 changes are associated with CAT changes. Methods: An observational study was performed using data obtained from 180 patients (mean 70.5 years) followed up for a year or more. A pulmonary function test was performed and CAT were determined every 6 months. Baseline 6 min walking distance (6MWD), dyspnea scale, BODE index, and emphysema severity detected on CT (LAA%) were examined. The annual exacerbation rate was determined during the study period. ΔCAT/year and ΔFEV1/year were expressed as the regression line slope. Linear regression analysis was performed to ascertain the effect of the clinical factors on ΔCAT. Results: The median follow-up duration was 2.1 years. The mean baseline CAT score and baseline %FEV1 were 13.9 (±SD 7.2) and 57.2 (21.2)%, respectively. The overall ΔCAT was -0.18(2.8). The mean ΔFEV1 was -43.4 (108.7) mL/yr. The ΔCAT was significantly correlated with the baseline CAT score, baseline FEV1, 6MWD, BODE, LAA%, and the exacerbation rate (p < 0.01 for all).During the observation period, no correlation was observed between ΔCAT and ΔFEV1. Multiple regression analysis showed a significant correlation between ΔCAT and baseline CAT score, BODE, LAA%, and exacerbation rate. Conclusion: Although a correlation was observed between baseline FEV1 and overall CAT score changes, the decline in annual FEV1 was not correlated.