TY - JOUR T1 - Prostaglandin D<sub>2</sub> and the role of the DP<sub>1</sub>, DP<sub>2</sub> and TP receptors in the control of airway reflex events JF - European Respiratory Journal JO - Eur Respir J SP - 1108 LP - 1118 DO - 10.1183/09031936.00061614 VL - 45 IS - 4 AU - Sarah A. Maher AU - Mark A. Birrell AU - John J. Adcock AU - Michael A. Wortley AU - Eric D. Dubuis AU - Sara J. Bonvini AU - Megan S. Grace AU - Maria G. Belvisi Y1 - 2015/04/01 UR - http://erj.ersjournals.com/content/45/4/1108.abstract N2 - Prostaglandin D2 (PGD2) causes cough and levels are increased in asthma suggesting that it may contribute to symptoms. Although the prostaglandin D2 receptor 2 (DP2) is a target for numerous drug discovery programmes little is known about the actions of PGD2 on sensory nerves and cough.We used human and guinea pig bioassays, in vivo electrophysiology and a guinea pig conscious cough model to assess the effect of prostaglandin D2 receptor (DP1), DP2 and thromboxane receptor antagonism on PGD2 responses.PGD2 caused cough in a conscious guinea pig model and an increase in calcium in airway jugular ganglia. Using pharmacology and receptor-deficient mice we showed that the DP1 receptor mediates sensory nerve activation in mouse, guinea pig and human vagal afferents. In vivo, PGD2 and a DP1 receptor agonist, but not a DP2 receptor agonist, activated single airway C-fibres. Interestingly, activation of DP2 inhibited sensory nerve firing to capsaicin in vitro and in vivo.The DP1 receptor could be a therapeutic target for symptoms associated with asthma. Where endogenous PGD2 levels are elevated, loss of DP2 receptor-mediated inhibition of sensory nerves may lead to an increase in vagally associated symptoms and the potential for such adverse effects should be investigated in clinical studies with DP2 antagonists.Prostaglandin D2 activates sensory nerves and evokes cough via DP1 receptors http://ow.ly/BR1kp ER -