RT Journal Article
SR Electronic
T1 Gene expression of EGFR, MINA53,MEN1 and MTOR in NSCLCs
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2709
VO 44
IS Suppl 58
A1 Dora Marinova
A1 Yanina Slavova
A1 Darina Kachakova
A1 Gergana Stancheva
A1 Atanaska Mitkova
A1 Radka Kaneva
A1 Danail Petrov
A1 Vanio Mitev
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P2709.abstract
AB Aim:To study the gene expression of Epidermal growth factor receptor(EGFR),MYC-induced nuclear antigen 53kDa(MINA53),Multiple endocrine neoplasia type 1(MEN1) and Mechanistic target of rapamycin(MTOR) in non-small cell lung carcinomas(NSCLC),and their correlations and prognostic significance.Methods:Surgically resected specimens from 57 NSCLC patients were studied:29 adenocarcinomas(AC) and 28 squamous cell carcinomas(SCC).Histological subtype,pTNM stage,survival and gene expression of EGFR,MINA53,MEN1 and MTOR were evaluated.Results:Overexpression of EGFR was found in 46%(17 SCC&9 AC),MINA53–54%(14SCC&17 AC),MEN1–53%(16SCC&14AC) and MTOR–25%(5SCC&9AC).Decreased expression of EGFR was found in 11%(2SCC&4 AC),MINA53–1 SCC,MEN1-2 AC and MTOR–5%(1 SCC&2 AC).Co-overexression of the 4 genes was found in 11%(4 SCC&2 AC).AC were more often with normal/decreased expression of EGFR(69%), while SCC-more often with overexpression(61%)(p=0.03),confirmed by regression analysis(Odds ratio 3.43;p=0.03).No prognostic significance of EGFR, MINA53,MEN1 or MTOR expression was found with Kaplain-Meier and Cox regression analysis (p>0.05).In SCC statistically significant correlations between EGFR&MEN1(p<0.001),EGFR&MTOR(p=0.01),MINA53&MTOR(p=0.004) and MEN1&MTOR(p=0.02) were observed.In AC statistically significant correlations between MINA53&MTOR(p=0.02) and MEN1&MTOR(p=0.01) were observed. MEN1 overexpression correlates with early stage(p=0.02).Conclusion:EGFR,MINA53,MEN1 and MTOR are often overexpressed in NSCLCs and there are positive correlations between their expression levels making them potential targets for combined therapy. They don't show a prognostic significance, although MEN1 overexpression correlate with early stage.