PT  - JOURNAL ARTICLE
AU  - Sergey Sterlikov
AU  - Vadim Testov
TI  - The risk of default in TB patients in the Russian Federation
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P2635
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P2635.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P2635.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - The risk of default in MDR-TB and non MDR-TB cohorts for new cases and previously treated patients was estimated.Methods. A prospective cohort review of patients treated in 2010 included: 1). 3.760 MDR-TB cases including 995 new TB cases, 534 relapses and 2231 other retreatment cases (1.297-after treatment failure, 161-after default and 773 – from group “other”); 2). 10.458 non MDR-TB patient including 7717 new cases, 1149 relapses and 1592 other retreatment cases). Absolute (AR) and relative risk (RR) of default were calculated.View this table:Risk of defaultResults. Treatment success and default rates comprised for: new MDR-TB cases – 60.7% and 15.4%; new non MDR-TB cases - 67.2% and 12.7%; MDR-TB relapses – 51.9% and 14.0%; non MDR-TB relapses – 54.0% and 12.4%; other MDR-TB retreatments – 39.2% and 21.4%; other non MDR-TB retreatments – 34.8% and 22.0% respectively. New MDR-TB cases demonstrated maximal RR of default due to increasing of treatment duration. There were not significant differences in the RR for MDR-TB and non MDR-TB patients with relapses and other retreatment cases. MDR-TB patients from group “treatment after default” demonstrated maximal AR of default and 30% of them resulted as defaulters.Conclusion. New MDR-TB patients have maximal RR of default but highest treatment success rate and they are focus group for default prevention tools.