PT - JOURNAL ARTICLE AU - Afroditi Sakellaropoulou AU - Andreas Giannopoulos AU - Katerina Haidopoulou AU - Maria Emporiadou AU - Maria Hatzistilianou TI - Late-breaking abstract: Does a relationship exist between mean platelet volume and left ventricular function in children with obstructive sleep apnea syndrome? DP - 2014 Sep 01 TA - European Respiratory Journal PG - P2278 VI - 44 IP - Suppl 58 4099 - http://erj.ersjournals.com/content/44/Suppl_58/P2278.short 4100 - http://erj.ersjournals.com/content/44/Suppl_58/P2278.full SO - Eur Respir J2014 Sep 01; 44 AB - Mean platelet volume (MPV), the most commonly used measure of platelet size, is a potential marker of platelet reactivity. Previous studies have reported increased platelet activation and aggregation in patients with obstructive sleep apnea syndrome (OSAS). Left ventricle hypertrophy (LVH) was defined as an Interventricular Septal Thickness at Diastole >12 mm.The aim of this study was to test if high MPV is associated with impaired cardiopulmonary function in children with OSAS.18 children with symptoms suggestive of OSAS were recruited. OSAS was verified with Sleep polysomnography. Blood samples were collected for measurements of MPV and other laboratory data. Doppler echocardiography was also assessed.Seven children (36.8%) had mild, 7 (36.8%) moderate and 5 (26.3%) had severe degree of OSAS. One child only had LVH and 12 (63.15%) had increased MPV.A positive correlation between MPV and BMI z score (p=0.019, r=0.548) was recorded, while a negative correlation exists between MPV and Apnea Hypopnea Index (p=0.590, r= - 0.136) and Apnea Index (p=0.259, r= - 0.281).Statistical importance difference was only found between MPV and left ventricular internal dimension z score during systole (LVIDs z score, p=0.05), but not with LVID z score during diastole (p=0.821), left ventricle internal dimension in diastole z score (LVPWd z score, p=0.159) and left ventricular posterior wall dimension during systole z score (LVPWs z score, p=0.481).In conclusion, it appears that a relation probably exists between MPV, left ventricular internal dimensions, obesity, and OSAS, but further studies are required to establish it.