@article {TeopompiP2099, author = {Elisabetta Teopompi and Panagiota Tzani and Marina Aiello and Maria Rosaria Gioia and Emilio Marangio and Alfredo Chetta}, title = {Excess ventilation and ventilatory constraints during exercise in patients with chronic obstructive pulmonary disease}, volume = {44}, number = {Suppl 58}, elocation-id = {P2099}, year = {2014}, publisher = {European Respiratory Society}, abstract = {Purpose: Excess minute ventilation (VE) for a given metabolic rate (VCO2) and ventilatory limitation occur in patients with chronic obstructive pulmonary disease (COPD) during exercise. The aim of the study was to investigate in COPD patients the relationship between VE/VCO2 and dynamic hyperinflation as well as tidal volume (VT) constraints during a cardiopulmonary exercise testing (CPET).Methods: Fifty-two (13 females) COPD patients performed a CPET. Slope and intercept of the VE/VCO2 linear relationship and changes in inspiratory capacity/total lung capacity (IC/TLC) as well as the ratios of VT at peak of exercise over vital capacity (VTpeak/VC) and IC (VTpeak/IC), as indices of volume excursion, and over forced expiratory volume at 1st second (VTpeak/FEV1), as exercise index of emphysema severity, were measured. The difference peak-rest in end-tidal pressure of CO2 (PETCO2) was also measured.Results: VE/VCO2 intercept increased as more as the dynamic hyperinflation was severe, by showing a negative correlation with IC/TLC peak (p\<0.01). VE/VCO2 intercept was positively related to VTpeak/FEV1 (p\<0.01) and to PETCO2 peak-rest (p\<0.01). Whereas, VE/VCO2 slope was negatively related to VTpeak/VC, VTpeak/IC and VTpeak/FEV1 (all correlations p\<0.05) and to PETCO2 peak-rest (p\<0.01).Conclusions: In COPD patients, VE/VCO2 slope and intercept may provide different and complementary information on the ventilatory limitation to exercise, as assessed by the changes in the end-expiratory lung volume and in the tidal volume excursion. The combined analysis of the excess ventilation and the ventilatory constraints during exercise may better define the COPD phenotypes.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/44/Suppl_58/P2099}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }