RT Journal Article
SR Electronic
T1 Peculiarities of the hormonal status and the clinical course of bronchial asthma developed in the perimenopausal period
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P1764
VO 44
IS Suppl 58
A1 Tetyana Chursinova
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P1764.abstract
AB The aim of this research was to study the clinical course and hormonal status of women with bronchial asthma (BA) which first-time onset in perimenopausal (peri-MP) period.Methods. The I gr. included 18 women with BA, developed in the peri-MP period, aged from 46 to 54 yrs (mean age 50,94±0,59 yrs). In gr. II included 24 perimenopausal women with asthma, which developed in the reproductive period, age from 44 to 55 yrs (mean age 49,38 ± 0,57 yrs).Physical examination, serum levels of follicle-stimulating (FSG), luteinizing hormones (LG), estradiol and progesterone were performed.Results. In 4 (22%) patients of I gr. had severe persistent asthma, 12 (67%) women had moderate persistent asthma, and mild persistent asthma was diagnosed only in 2 patients (11%). Comorbidity analysis in patients of I gr. determined that in 11 (61%) patients asthma was associated with allergic rhinitis, in 8 (44%) patients – with sinusitis, obesity I st. was detected in 10 patients (56%) and body mass index (BMI) was ranged from 30.7 to 34.8 kg/m2 (mean 32,57±0,41 kg/m2), in 2 patients (11%) had hypertension. In patients of I gr. had determined a significant decrease of estradiol (p=0.001) and progesterone (p=0.029) compared with hormone concentrations in patients of II gr. There were no significant differences in levels of FSH, LG (p>0,05) between patients of both groups.Conclusion. Bronchial asthma which developed in the perimenopausal period was characterized by severe and moderate course, patients requiring long-term corticosteroid therapy. Hormonal status of patients was characterized by decreasing levels of estradiol and progesterone, these disorders require correction.