TY - JOUR T1 - Effects of alveolar hypoventilation on nighttime plasma glucose in obese patients JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P1532 AU - Annette Marie Moll AU - Simone Rack AU - Claudius Teupe AU - Albert Moeller Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P1532.abstract N2 - Introduction: Obstructive sleep apnea (OSA) is associated with alterations in glucose metabolism in obese individuals. However, it is not known whether an additive alveolar hypoventilation (aHyp) with nighttime hypercapnia and hypoxemia is a predictor of glycemic control.Methods: We performed a prospective study in 119 patients with OSA and a body mass index (BMI) > 30 kg/m². They underwent a polysomnography with transcutaneous ptcCO2 measurements in our sleep laboratory. Additionally we registered the nighttime plasma glucose (mg/dl) by capillary blood gas analysis on 10:00 pm, 01:00 am and 05:00 am.Results: We detected in 58/117 patients with severe OSA (AHI (/h) 54,8±27,1; BMI (kg/m²) 41,1±6,86) a nighttime hypercapnia. We found a significantly increased incidence of diabetes mellitus (T2D) in patients with aHyp. (52% vs. 31%; p=0,028)In general, the nighttime plasma glucose (mg/dl) was higher in patients with aHyp. (10:00 pm: OSA: 130,5±53,3 vs. aHyp: 147,7±68,4; 01:00 am: 118,3±37,9 vs. 133,2±45,9; 05:00 am: 120,7±21,2 vs. 133,8±44,9).For further analysis, we excluded patients with T2D. We compared patients with OSA and aHyp (OSA: n=18; aHyp: n=17) with similar AHI (/h) (OSA: 47,9±27,8 vs. aHyp: 61,5±28,8; p=0,165) and BMI (OSA: 37,5±4,9 vs. aHyp: 40,1±6,2; p=0,188) and observed significantly higher plasma glucose levels (mg/dl) in patients with aHyp (10:00 pm: OSA: 107,5±14,2 vs. aHyp: 126,3±24,7, p=0,013; 01:00 am: 103,8±8,3 vs. 117,8±17,9, p=0,026; 05:00 am: 111,1±8,5 vs. 117,7±12,8, p=0,134).Conclusions: Our findings suggest that alveolar hypoventilation with nighttime hypercapnia may be an additional factor in obese patients with severe OSA for developing type 2 diabetes. ER -