TY - JOUR T1 - Screening for latent tuberculosis before tumour necrosis factor antagonist therapy JF - European Respiratory Journal JO - Eur Respir J SP - 1512 LP - 1513 DO - 10.1183/09031936.00020315 VL - 45 IS - 5 AU - Michael R. Loebinger AU - Anton Pozniak Y1 - 2015/05/01 UR - http://erj.ersjournals.com/content/45/5/1512.abstract N2 - We thank Richard Hewitt and colleagues for their comments. Determining the best strategy and combination of tests for detection of latent tuberculosis (TB) infection (LTBI) is limited by the lack of gold standard for the diagnosis of LTBI. Increasing the number of tests may improve the sensitivity of latent TB detection, but at the cost of specificity, with an increased false-positive rate. A negative IGRA is an adequate, pragmatic screening tool in patients commencing TNF antagonists http://ow.ly/JXyAA ER -