TY - JOUR T1 - Childhood wheeze phenotypes and atopy over adolescence JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P1197 AU - Caroline Lodge AU - Adrian Lowe AU - Katrina Allen AU - Melanie Matheson AU - Paul Thomas AU - Catherine Bennett AU - Christine Axelrad AU - Bircan Erbas AU - Cecilie Svanes AU - David Hill AU - Clifford Hosking AU - Michael Abramson AU - S. Dharmage Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P1197.abstract N2 - BackgroundAtopy is linked with asthma severity and persistence in childhood, but adolescent atopic outcomes of wheeze phenotypes defined by latent class analysis (LCA) are unknown.AimDetermine adolescent atopic outcomes of LCA defined childhood wheeze phenotypes (0-7 years)MethodA high-atopy risk birth cohort recorded atopic outcomes (sensitization, eczema, hay fever and expired Nitric oxide [eNO]) at 12(N=375) and/or 18 years(N=411). Regression analyses investigated associations between atopic outcomes and phenotypes of: Early Transient, Early Persistent, Intermediate Onset and Late Onset wheeze, whilst adjusting for confounders including baseline 'atopic variables'.ResultsView this table:Although all persistent wheezing phenotypes had increased risk of atopy, Intermediate Onset (onset at ∼ 1.5-2years) was the most atopic group, whilst Early Transient had a reduced risk.ConclusionAdolescent atopy risk differs between childhood wheeze phenotypes. Intermediate onset wheeze is the most atopic, whilst findings on Early Transient wheeze may reflect protective effects of early life microbial exposure. These differences may inform long term prognosis and provide clues concerning aetiology. ER -