RT Journal Article
SR Electronic
T1 Cellular composition of bronchoalveolar lavage (BAL) as inflammation indicator in patients with chronic obstructive pulmonary disease (COPD)
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P707
VO 44
IS Suppl 58
A1 Vukoica Karlicic
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P707.abstract
AB INTRODUCTION:COPD is characterized by constant and progressive airflow restriction due to chronic inflammation in the airways of the lung caused by harmful gases and particles. Comorbidity in COPD is a consequence of systemic inflammation, or occurs as a result of spreading inflammatory processes from lung to systemic circulation.AIM: Estimate the possibility to determine the inflammation level in the lungs and the importance of inhaled corticosteroids with/without long acting beta agonist in treatment of patients with COPD, based on cell analyses of bronchoalveolar lavage (BAL).METHOD AND PATIENTS:In 58 patients, COPD was diagnosed; 18 patients in I GOLD stage, 16 in II GOLD stage, 12 in III GOLD stage and 8 patients in IV GOLD stage. All patients underwent functional diagnostic of the lung, MSCT, video bronchoscopy with BAL and cytological analysis of BAL.RESULTS: I GOLD stage, 19,8% lymphocytes in BAL and 26,9% neutrophils.II GOLD stage,21,2% lymphocytes in BAL and 41% neutrophils.III GOLD stage,9,1% lymphocytes in BAL and 55,2% neutrophils.IV GOLD stage 4,4% lymphocytes in BAL 78,1% neutrophils.CONCLUSION:Lymphocytes are inversely proportional, and leucocytes are directly proportional to COPD stage. There is larger number of lymphocytes in I and II GOLD stage, while neutrophils number increases from I to IV GOLD stage.As neutrophils in BAL rise, lung function decreases.