RT Journal Article
SR Electronic
T1 Late-breaking abstract: Predictors of restrictive spirometry pattern in large population based studies. Is there a role for occupational exposures?
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 3204
VO 44
IS Suppl 58
A1 Giulia Paolocci
A1 Nicola Murgia
A1 Jonas Brisman
A1 Anna.Carin Olin
A1 Giacomo Muzi
A1 Kjell Torén
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/3204.abstract
AB Background:Epidemiological studies have found that 7-13% of adults have FVC values <80% of the predicted value with a FEV1/FVC ratio ≥70%. This pattern was described as a suggestive for a restricitive ventilatory defect when lung volumes are not available.Recognized predictors of this pattern are age, body mass index (BMI) and smoking habits, while little is known about the influence of occupational exposures.Aims:the objective of this study is to evaluate predictors of restrictive pattern, including several potential occupational risk factors.Methods:A general population sample of 3645 subjects was selected from the population register in Göteborg, Sweden.Restrictive pattern was defined as having FVC values <80% of the predicted value with a FEV1/FVC ratio ≥70%.Information on predictors and confounders were gathered by a questionnaire, occupational exposure were classified by a job exposure matrix.Regression models were used to test predictors and confounders.Results:71 subjects (2%) had a restrictive ventilatory defect. Risk factors for a restrictive pattern were male gender, BMI, low birth weight, being non-swedish born.Among subjects overweight, alongside the before mentioned risk factors, occupational exposure to textile fibres and leather dust was associated with a restrictive pattern (OR 3.4, 95%CI 1.05-11).Conclusions: A restrictive ventilatory defect in spirometry is not a common finding.In our study overweight blue-collar workers, exposed to textile and leather dust, are at higher risk of restricitive pattern.This interesting finding needs to be confirmed in studies considering also lung volumes.