@article {FitzGerald1894, author = {J. Mark FitzGerald and Huib Kerstjens and Pierluigi Paggiaro and Ken Ohta and Masakazu Ichinose and Petra Moroni-Zentgraf and Michael Engel and Hendrik Schmidt and Eric Bateman}, title = {Once-daily tiotropium respimat add-on to ICS{\textpm}LABA improves control across asthma severities}, volume = {44}, number = {Suppl 58}, elocation-id = {1894}, year = {2014}, publisher = {European Respiratory Society}, abstract = {Background: Tiotropium Respimat added to ICS{\textpm}LABA has been investigated across asthma severities. We present ACQ-7 responses from six Phase III randomised, double-blind, placebo-controlled, parallel-group trials in patients with symptomatic asthma.Methods: Two 48-wk trials (PrimoTinA): 5{\textmu}g added to ICS (>=800{\textmu}g budesonide or equivalent [bud or eq])+LABA; two 24-wk trials (MezzoTinA): 5/2.5{\textmu}g added to ICS (400{\textendash}800{\textmu}g bud or eq); 12-wk trial (GraziaTinA): 5/2.5{\textmu}g added to ICS (200{\textendash}400{\textmu}g bud or eq); 52-wk trial (Study 464): 5/2.5{\textmu}g added to ICS (400{\textendash}800{\textmu}g bud or eq). ACQ-7 responder rates were pre-specified in MezzoTinA, GraziaTinA and Study 464; ACQ-7 change from baseline (response) was pre-specified in PrimoTinA.Results: Mean baseline ACQ-7 (SD): PrimoTinA 2.63 (0.69); MezzoTinA 2.18 (0.49); GraziaTinA 2.10 (0.42); Study 464 1.95 (0.39). ACQ-7 responder rate data are presented (Table). Adjusted mean response difference vs placebo Respimat{\textpm}SE: PrimoTinA, 5{\textmu}g -0.132{\textpm}0.049 (p=0.007); MezzoTinA, 5{\textmu}g -0.115{\textpm}0.043 (p=0.008), 2.5{\textmu}g -0.160{\textpm}0.043 (p\<0.001); GraziaTinA, 5{\textmu}g 0.014{\textpm}0.067 (p=0.835), 2.5{\textmu}g 0.061{\textpm}0.067 (p=0.362). Mean ACQ-7 (SD) in Study 464: 0.98 (0.63), 1.09 (0.72) and 0.99 (0.68) for 5{\textmu}g, 2.5{\textmu}g and placebo.Conclusion: Once-daily tiotropium Respimat add-on to at least ICS maintenance therapy was associated with improved asthma control across severities.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/44/Suppl_58/1894}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }