RT Journal Article
SR Electronic
T1 Comparison between spirometry and computed tomography to evaluate dynamic hyperinflation in COPD patients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P549
VO 44
IS Suppl 58
A1 Danilo Berton
A1 Álvaro Santos
A1 Bruno Hochhegger
A1 Ivo Bohn, Jr.
A1 Rodrigo Lima
A1 Vanderléia Breda
A1 Paulo Teixeira
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P549.abstract
AB Background: Dynamic hyperinflation (DH) is a key mechanism related with dyspnea and exercise intolerance in COPD patients. Quantitative computed tomography (CT) measurements strongly correlate with physiologic measurements of airway obstruction; however nothing is known about its relationship with physiological assessment of DH.Aims: Compare the effects of metronome-paced hyperventilation (MPH) on lung volumes evaluated by spirometry and CT densitovolumetry (CTd) in patients with moderate COPD (50%≤FEV1<80%pred).Methods: 16 patients with COPD (60.7±10.7 yr; FEV<sub style="text-align: justify;">1= 70±7% pred) after a 1-wk wash-out period using only short acting BD as rescue medication performed spirometry and CTd before and after MPH (respiratory rate twice the baseline rate for 30s).Results: Patients ranged from normal to slightly/moderately hyperinflated at rest (TLC: 109±14; FRC: 121±24; and RV: 125±36 % predicted). After MPH, inspiratory capacity (IC) significantly reduced, indicating DH. Nevertheless, CTd measurements did not change significantlyView this table:Measurements before and after metronome-paced hyperventilation (MPH)..Conclusions: In the present sample, quantitative CT measurements were insensitive to detect DH in patients with moderate COPD.