PT  - JOURNAL ARTICLE
AU  - Ivanka Galeva
AU  - Sirma Mileva
AU  - Milena Yankova
AU  - Silvia Andonova
AU  - Nadezhda Yaneva
AU  - Alexey Savov
TI  - Gene variant rs2305480 C>T in gasdermin B gene (GSDMB) among Bulgarian children with recurrent wheezing
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P4781
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P4781.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P4781.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Objective:The gasdermin B (GSDMB) gene is located at 17q21.2 and recent reports suggest that GSDMB is associated with childhood asthma in several populations. We investigated the association of a SNP in GSDMB (rs2305480C>T) with recurrent wheezing, severity of bronchial obstruction and family history of asthma and allergy.Materials and Methods:Family history of asthma and allergy, recurrent wheezing and atopy were assessed in 93 infants admitted to the hospital for bronchiolitis. All children were genotyped for rs2305480C>T by PCR RFLP analysis. The presence of AvaII restriction site was indicated by C-allele and the absence - by T-allele.Results:Data were analyzed as a recessive genetic model. Genotype frequencies did not deviate significantly from expected under the Hardy-Weinberg Equilibrium - T/T genotype was 18%, C/T - 47% and C/C - 35%. Our data show that the genotype T/T is a possible risk factor for recurrent wheezing (OR 3,68, 95%, CI= 0,98-13,76). Children homozygous for T-allele are more likely to have a family history of allergy and asthma (OR 5,41, 95%, CI= 1,43-20,47) and early age of first wheezing - 6,88 mo compared to 10,4 mo for C/C, p= 0,02.Conclusions:Our results support the role of GSDMB SNP (rs2305480C>T) for determining asthma phenotypes in preschool children.The study was financially supported by research grant (2013), Medical University - Sofia.