PT  - JOURNAL ARTICLE
AU  - Viktoriya Kamenir
AU  - Daria Kalashnyk
AU  - Olga Korotchenko
AU  - Elena Hetman
TI  - Assessment of treatment efficiency in patients with chronic obstructive pulmonary disease combined with gastroesophageal reflux disease during treatment with melatonin
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P3571
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P3571.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P3571.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - The AIM: To evaluate the impact of the additional treatment with melatonin in 6 months after the treatment in patients with chronic obstructive pulmonary disease (COPD) in combination with gastroesophageal reflux disease (GERD).Materials and Methods:we observed 131 patients. There were 62 patients with COPD combined with GERD, 39 patients with GERD and 30 control individuals. Patients of the 1st group were divided into 2 subgroups: 1a - received standard treatment of COPD and GERD + melatonin 3mg per day, 1b - the standard treatment of COPD and GERD, 2 - standard treatment ofGERD.We evaluatedthe number of COPD exacerbations in 6 months after the treatment.Results: In 6 months after the treatment we found 32,2% more non-exacerbated COPD in group of patients taken melatonin. 1 COPD exacerbation took place 19,7% more often, 2 exacerbations 9,7% more often and 3 exacerbations 3,2% more often in subgroup 1b (p = 0,001).No significant differences in spirometric indices were found in any subgroup with comorbid diseases after the treatment and in 6 months after the treatment. This point can be assessed as a positive indicator of prescribed treatment.Conclusions : Patients additionally received melatonin had significantly lower number of COPD exacerbations during 6 months after treatment compared with patients who did not take.Thus, combination of melatonin with standard treatment of COPD conjuncted with GERD gives a fairly long-lasting positive effect.