TY - JOUR T1 - Invasive pulmonary procedures with biopsy can be performed without inducing metabolic activity JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P662 AU - Pradeesh Sivapalan AU - Sara Colella AU - Klaus Richter Larsen AU - Bente Krogsgaard Schaadt AU - Paul Frost Clementsen Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P662.abstract N2 - IntroductionFluorine 18 fluorodeoxyglucose positron emission tomography computer tomography (PET-CT) has a high sensitivity in detection of malignancy in patients suspected of lung cancer, but is not specific. Also inflammatory reactions can result in metabolic activity. It is presumed, that procedures with biopsies will also result in false positive results. Therefore, PET CT is normally performed prior to taking biopsies.AimTo investigate if invasive pulmonary procedures with biopsies from benign lesions can be followed by PET negative results, in other words to find out, if a biopsy can be made without inducing PET activity.MethodsWe searched in a three year period for patients suspected of lung cancer having (1) PET CT performed after biopsy, (2) interval 1 – 5 days and (3) PET negative results in sites biopsied with the finding of normal tissue.ResultsEighty-three patients fulfilled (1), twenty of these also (2) and eight also (3). In these 8 patients, the PET negative findings were seen after bronchoscopy with forceps biopsy in 3 patients, after CT guided lung biopsy (18 G needle) in 2 patients and after EBUS-TBNAB (22 G) from chest lymph nodes in 3 patients. PET positive findings demonstrated malignancy or other abnormal tissue, if biopsied.ConclusionInvasive pulmonary procedures with biopsy do not necessarily result in PET activity. Therefore, PET positive results should always be taken seriously even shortly after taking biopsies.ReferenceKobayashi Ket al. Radiographics 2012; 32(5): 1483-501. ER -