TY - JOUR T1 - Validation of the global lung function initiative (GLI) spirometry reference equations in school age Spanish children JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P4519 AU - Ignacio Iglesias AU - Maite Benavides AU - Yanny Paola Delgado AU - Inés Mir AU - Sandra Rovira AU - Alba Torrent AU - Silvia Gartner AU - Antonio Moreno-Galdó Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P4519.abstract N2 - Introduction. Recently published multi-ethnic spirometry reference equations for Caucasian subjects from 3 to 95 years (Quanjer et al Eur Respir J 2012) provide a worldwide standard for interpreting spirometric test results.Objective. To assess how well the GLI equations fit spirometry data from "healthy" Spanish school age children, in order to verify the appropriateness of this reference for clinical use in this population.Methods. Two spirometric measurements (n=722/603) were obtained, according to ERS/ATS guidelines, at 7 randomly selected schools from Barcelona (Spain) in children aged 7 to 14.9 years, with a mean (SD) interval between the two tests of 54.3 days (35.3) (range 10 – 135 days). Z-scores were calculated for the spirometry outcomes based on the GLI equations. If there was no offset between the reference and test populations, the mean (SD) z-scores of the test population would be 0 (1). A difference of ≥ 0.5 z-score was considered to be clinically significant.Results. Of 722 children recruited, 662 were White and 442 (66.8%) fulfilled our criteria as 'healthy'. Of these 71.9% performed technically acceptable and reproducible manoeuvres.View this table:Conclusions. The finding of values outside 0.5 z-scores of GLI predicted values suggests poor fit with GLI equations. Reasons for these discrepancies should be investigated before applying the GLI equations in Spanish school age children. ER -