TY - JOUR T1 - Factors of cardiac dysfunction in advanced COPD JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P537 AU - Natalia Porakhonko AU - Irina Lapteva AU - Olga Kharevich AU - Elena Lapteva AU - Irina Orlova Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P537.abstract N2 - Introduction: a few studies have investigated the role of abnormal lung function for cardiac dysfunction in patients with COPD according to the different presenting phenotypes.Aim: to study how the airflow limitation with static hyperinflation, especially in emphysema phenotype, influences cardiac performance.Methods: subjects with advanced COPD were divided according to the findings from chest high resolution computed tomography (HRCT) in 3 different phenotypes: chronic bronchitis (n=16), emphysema (n=19) and their combinations (n=20).All the patients were examined using lung function tests (spirometry, body plethysmography and diffusion capacity) and Doppler echocardiography for evaluation planimetric and haemodynamic cardiac parameters.Analysis of variance (ANOVA) was performed to study the differences of cardiac chamber sizes and heart function across phenotypes. Pearson correlations were performed to analyze the associations between variables of lung function and cardiac chamber sizes. The independent associations between IC/TLC and cardiac chamber size were tested by multivariate linear regression analysis.Results: static hyperinflation (IC/TLC, functional residual capacity, and residual volume) showed stronger associations with cardiac chamber size than airway obstruction or diffusion capacity for carbon monoxide. IC/TLC was considered as an independent predictor of a decreasing cardiac chamber size at multivariate linear regression analysis.Conclusions: patients with hyperinflation (IC/TLC≤0.25) in COPD have an impaired left ventricular diastolic filling. The decreasing heart size not only is present in severe emphysema but also shows a substantial association with hyperinflation. ER -