TY - JOUR T1 - Lack of association between increased mitochondrial DNA 4977 deletion and ATP levels of sputum cells from chronic obstructive pulmonary disease patients versus healthy smokers JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P4191 AU - Ayla Karimova AU - Duran Üstek AU - Murat Kara AU - Bülent Tutluoglu AU - Hülya Azakli AU - Ilhan Onaran Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P4191.abstract N2 - Levels of the mtDNA mutation including the 'common' 4977 bp mtDNA deletion is elevated in lung tissue of smokers relative to non-smokers.In this study we looked at smokers with and without COPD in order to evaluate the incidence of mtDNA4977 and mtDNA copy number in sputum cells and in peripheral blood leukocytes (PBLs) in relation to cellular ATP and oxidative stress statusView this table:Characteristics of Subjects.The frequency of occurrence of this 4977 bp mutation was significantly higher proportion in the sputum cells of patients with COPD compared to smokers without COPD (p<0.0001). Therephore, accumulation of mtDNA 4997 in sputum cells of smokers with COPD does not seem to have an important impact on mitochondrial dysfunction in terms of ATP production when compared to those of healthy. ER -